active site

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active site

n.
The part of an enzyme at which catalysis of the substrate occurs.

ac·tive site

(ăk′tĭv)
The part of an enzyme where the substance that the enzyme acts upon (called the substrate) is catalyzed. See more at enzyme.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.active site - the part of an enzyme or antibody where the chemical reaction occurs
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
References in periodicals archive ?
2) The catalytic site is located in the [beta] subunit, although residues from the [alpha] subunit are also required for ATP hydrolysis.
The peculiar feature of lipases is the presence of a/AY hydrolase fold in the N-terminal domain which contains a buried active site in the form of a catalytic triad which is similar to the catalytic site of chemotrypsin, trypsin, serine proteases and other esterases (Brzozowski et al.
Specifically, the researchers studied the binding and activation of the substrate water molecules in the catalytic site of photosystem II.
Comparison of our homology model with some crystallographic structures of IN for other viruses, such as: HIV-1 (1BIZ), VSA (1VSD, 1VSH) and PFV (3DLR) showed a high similarity structure, especially in the positions of the amino acid of the catalytic site, Asp15, Asp72 and Glu108, suggesting that these amino acids are very important for the enzymatic function of IN.
A new collaborative study at the University of Virginia (USA) details for the first time a new type of catalytic site where oxidation catalysis occurs, shedding new light on the inner workings of the process.
The model allowed the researchers to visualize and track how oxygen and hydrogen travel to the hydrogenase's catalytic site, where the gases bind, and what routes the molecules take as they exit.
The peptide most likely recognizes the catalytic site in intact PSA as it does not recognize PSA inactivated by partial cleavage of certain peptide bonds (15).
The following steps might occur sequentially in the hydrolysis of PC: (1) Binding of PC to Site I; (2) Transfer of the acyl group at sn-2 to the catalytic site and simultaneous binding of the resultant lysoPC to Site II; (3) Transfer of sn-2 acyl group to H2O; (4) Transfer of sn-1 acyl group to the catalytic site; (5) Transfer of sn-1 acyl group to H2O.
4 kcal/mol), indicating dihydrotanshinone has similar affinity to quinidine in binding to the catalytic site on CYP2D6.
m], the efficiencies of these substrates decreased approximately two- to sixfold for proteinases such as trypsin and chymotrypsin, which have a relatively accessible catalytic site.
There had been a lot of confusion about how DNA enters the polymerase and how the DNA is oriented relative to the catalytic site," notes Stillman.