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Related to Cathepsins: Cathepsin L


Any of various enzymes found in animal tissue that catalyze the hydrolysis of proteins into smaller proteins.

[German Kathepsin, from Greek kathepsein, to digest : kat-, kata-, cata- + hepsein, to boil.]


(Biochemistry) a proteolytic enzyme responsible for the autolysis of cells after death
[C20: from Greek kathepsein to boil down, soften]


(kəˈθɛp sɪn)

any of a class of intracellular enzymes that break down protein in certain abnormal conditions and after death.
[1925–30; < Greek kathéps(ein) to digest]
ca•thep′tic (-tɪk) adj.
References in periodicals archive ?
Proteases that have been chosen for this purpose are caspases, legumain and cathepsins B, L and S for which I will synthesize very specific, small molecule radiolabeled inhibitors suitable for mass cytometry approach.
Utilizing its expertise in cysteine cathepsins as a platform, Virobay has the opportunity to help treat neuropathic pain, autoimmune diseases and fibrosis," stated Mr.
As well, both substrates provide minimal (if any) cross-reaction with other cathepsins.
In the current study, Kallunki and colleagues discovered that ErbB2 induces expression of proteins called cathepsins.
Balicatib inhibited not only cathepsin K, but also cathepsins B and L.
Specific topics include the age-dependence of neuronal apoptosis and of caspase activation, the significant role of apoptosis-inducing factor for brain damage following focal cerebral ischemia, the role of [micro]-calpain I and lysosomal cathepsins in hippocampal neuronal necrosis after transient global ischemia in primates, mitochondrial damage in traumatic central nervous system injury, hypoglycemic neuronal death, and the suspected role of a multi-functional protein--Tumor Suppressor p53--in seizure-induced neuronal cell death.
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsins in adipose tissue and in circulation.
Baden notes that his team's experiments in mice showed that brevetoxins can also depress an animal's response to infection by inactivating cathepsins, enzymes that immune cells use to break down debris as they attack it.
1992); and c) cathepsins located within macrophages and B-lymphocytes play an important role in the formation of antigenic determinants essential for both humoral and cell-mediated immune responses (Katunuma et al.
inflammation (elastases, cathepsins, matrix metalloproteinases, and phospholipases); cancer (protein typrosine kinase, matrilysin, collagenase IV); acne (transglutaminase).