Potential role(s) of cysteine cathepsins
in cancer progression and metastasis.
Proteases that have been chosen for this purpose are caspases, legumain and cathepsins
B, L and S for which I will synthesize very specific, small molecule radiolabeled inhibitors suitable for mass cytometry approach.
Utilizing its expertise in cysteine cathepsins
as a platform, Virobay has the opportunity to help treat neuropathic pain, autoimmune diseases and fibrosis," stated Mr.
VBY-891 is also highly selective against human cathepsins
L, B, F and K.
As well, both substrates provide minimal (if any) cross-reaction with other cathepsins
In the current study, Kallunki and colleagues discovered that ErbB2 induces expression of proteins called cathepsins
Balicatib inhibited not only cathepsin
K, but also cathepsins
B and L.
Specific topics include the age-dependence of neuronal apoptosis and of caspase activation, the significant role of apoptosis-inducing factor for brain damage following focal cerebral ischemia, the role of [micro]-calpain I and lysosomal cathepsins
in hippocampal neuronal necrosis after transient global ischemia in primates, mitochondrial damage in traumatic central nervous system injury, hypoglycemic neuronal death, and the suspected role of a multi-functional protein--Tumor Suppressor p53--in seizure-induced neuronal cell death.
in human obesity: changes in energy balance predominantly affect cathepsins
in adipose tissue and in circulation.
Baden notes that his team's experiments in mice showed that brevetoxins can also depress an animal's response to infection by inactivating cathepsins
, enzymes that immune cells use to break down debris as they attack it.
1992); and c) cathepsins
located within macrophages and B-lymphocytes play an important role in the formation of antigenic determinants essential for both humoral and cell-mediated immune responses (Katunuma et al.
inflammation (elastases, cathepsins
, matrix metalloproteinases, and phospholipases); cancer (protein typrosine kinase, matrilysin, collagenase IV); acne (transglutaminase).