This patented approach is designed to help the body's immune system overcome its "self-tolerance" to prostate cancer cells and mount a strong targeted CD8+ killer T cell response
to eliminate the cancerous cells displaying these antigens.
Led by Chenggang Jin, MD, PhD, head of immunology at Pharmasan Labs, the study authors tested and validated a novel T cell-based assay for the detection of antigen-specific T cell response
to Borrelia burgdorferi, the causative agent of Lyme disease.
The cancer stem cells inhibit T cell response
, and it is these T cells that recognize and eradicate cancer," she added.
The reciprocal expression pattern of these receptors may indicate they have opposing functions in regulating the kinetics of the T cell response
and memory cell evolution.
There is a developing understanding that how tightly MHC binds its peptide determines whether you get a T cell response
," says team member Lawrence J.
The standard uncertainty in the load cell response
R that is associated with the NIST Quantum Electrical Metrology Division determination of these calibration factors is
Powell said, "I am optimistic that we have achieved a breakthrough in methods to prime a potent T cell response
to individual MHC class II epitopes for various infectious diseases.
Elispot measures interferon-gamma, which has been used to indicate a CD8 T cell response
Researchers at the University of California, Los Angeles studied the effect of disposition and situational optimism on the number of helper T-cells and the natural killer cell response
This study gives us an important opportunity to evaluate a novel treatment approach using a DNA vaccine platform to increase immune activation by generating a robust in-vivo T cell response
, especially in the tumor, and potentially decreasing tumor recurrence in HPV positive head and neck cancer patients.
Boosting the antigen-specific T-helper cell response
is critical to getting strong, prompt humoral and cytotoxic T-cell response
for complete and rapid control of infection.
Finally, experimental data from studies in rhesus monkeys infected with Simian Immunodeficiency Virus (SIV) indicate that viral control is a function of the antiviral CD8 "F cell response