The two cell-cycle
kinases CDK4 and CDK6 normally facilitate cell-cycle
progression but are abnormally activated in certain cancers.
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle
Knockdown of Sec 8 promotes cell-cycle
arrest at G/S phase by inducing p21 via control of FOXO proteins.
Nakayama KI, Nakayama K: Ubiquitin ligases: Cell-cycle
control and cancer.
checkpoints are defined as mechanisms that regulate the cell cycle by monitoring key molecular processes involved and blocking their progression until these processes have been accurately completed.
Categories in which the proportion of IR-responsive genes exceeded expectation based on chance included cell cycle, cell proliferation, DNA and RNA metabolism, M phase of mitotic cell cycle, S phase of mitotic cell cycle, response to DNA damage stimulus, DNA repair, and cell-cycle
checkpoint (Table 2).
Although p53 is a key cell-cycle
regulator, reduced p53 activity didn't pose a danger in bladder cancer patients who had normal p21 levels.
Several new agents in development seek to achieve this goal, including immune system modulators (such as MAbs and immunotoxins), cell-cycle
inhibitors, proteasome inhibitors, apoptosis inducers, and angiogenesis inhibitors.
Only then can this protein efficiently stimulate the transcription of cell-cycle
inhibitors (Bartek and Lukas 2001; Lukas et al.
control is a process that is most often misregulated in human disease, he said.
He gives an overview of the cell cycle, then addresses the issues of model organisms in cell-cycle
analysis, the cell-cycle
control system, chromosome duplication, early mitosis, assembly of the mitotic spindle, the completion of mitosis, cytokinesis, meiosis, control of cell proliferation and growth, the DNA damage response, and the cell cycle in cancer.
Mice in the latter group were therefore susceptible to benzene's direct genotoxic leukemogenicity, whereas those in the former still experienced epigenetic leukemogenicity via cell-cycle
perturbations despite DNA repair.