cell cycle

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cell cycle

n.
The series of events involving the growth, replication, and division of a eukaryotic cell.

cell cycle

n
(Genetics) the growth cycle of eukaryotic cells. It is divided into five stages, known as G0, in which the cell is quiescent, G1 and G2, in which it increases in size, S, in which it duplicates its DNA, and M, in which it undergoes mitosis and divides

cell′ cy`cle


n.
the cycle of growth and asexual reproduction of a cell, consisting of interphase followed in actively dividing cells by prophase, metaphase, anaphase, and telophase.
[1970–75]
References in periodicals archive ?
The two cell-cycle kinases CDK4 and CDK6 normally facilitate cell-cycle progression but are abnormally activated in certain cancers.
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.
Knockdown of Sec 8 promotes cell-cycle arrest at G/S phase by inducing p21 via control of FOXO proteins.
Cell-cycle checkpoints are defined as mechanisms that regulate the cell cycle by monitoring key molecular processes involved and blocking their progression until these processes have been accurately completed.
Categories in which the proportion of IR-responsive genes exceeded expectation based on chance included cell cycle, cell proliferation, DNA and RNA metabolism, M phase of mitotic cell cycle, S phase of mitotic cell cycle, response to DNA damage stimulus, DNA repair, and cell-cycle checkpoint (Table 2).
Although p53 is a key cell-cycle regulator, reduced p53 activity didn't pose a danger in bladder cancer patients who had normal p21 levels.
Several new agents in development seek to achieve this goal, including immune system modulators (such as MAbs and immunotoxins), cell-cycle inhibitors, proteasome inhibitors, apoptosis inducers, and angiogenesis inhibitors.
Only then can this protein efficiently stimulate the transcription of cell-cycle inhibitors (Bartek and Lukas 2001; Lukas et al.
Cell-cycle control is a process that is most often misregulated in human disease, he said.
He gives an overview of the cell cycle, then addresses the issues of model organisms in cell-cycle analysis, the cell-cycle control system, chromosome duplication, early mitosis, assembly of the mitotic spindle, the completion of mitosis, cytokinesis, meiosis, control of cell proliferation and growth, the DNA damage response, and the cell cycle in cancer.
Mice in the latter group were therefore susceptible to benzene's direct genotoxic leukemogenicity, whereas those in the former still experienced epigenetic leukemogenicity via cell-cycle perturbations despite DNA repair.