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sensitization
(redirected from Central sensitization)

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
sen·si·tize  (sns-tz)
v. sen·si·tized, sen·si·tiz·ing, sen·si·tiz·es
v.tr.
1. To make sensitive: "The polarity principle . . . sensitizes the observer to the coexistence of seemingly contradictory phenomena" (Heinz Eulau).
2. To make (a film or plate) sensitive to light, especially to light of a specific wavelength.
3. To make hypersensitive or reactive to an antigen, such as pollen, especially by a second or repeated exposure.
v.intr.
To become sensitive or hypersensitive.


sensi·ti·zation (-t-zshn) n.
sensi·tizer n.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.sensitization - the state of being sensitive (as to an antigen)
irritation - (pathology) abnormal sensitivity to stimulation; "any food produced irritation of the stomach"
predisposition, sensitivity - susceptibility to a pathogen
2.sensitization - (psychology) the process of becoming highly sensitive to specific events or situations (especially emotional events or situations)
physical process, process - a sustained phenomenon or one marked by gradual changes through a series of states; "events now in process"; "the process of calcification begins later for boys than for girls"
psychological science, psychology - the science of mental life
3.sensitization - rendering an organism sensitive to a serum by a series of injections
immunisation, immunization - the act of making immune (especially by inoculation)


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Central sensitization appears to be the common denominator among fibromyalgia, interstitial cystitis, diffuse low back pain, chronic fatigue syndrome, irritable bowel syndrome, and headache syndromes, with resulting amplified pain sensations.
The etiology of the muscular pain has yet to be conclusively determined, and hypotheses are moving away from peripheral causes, such as local muscle ischemia and microtrauma (Simms, 1998), toward etiologies that may involve central sensitization and lowered pain thresholds (Bennett, 1996; Crofford & Demitrack, 1996; Weigent, Bradley, Blalock, & Alarcon, 1998).
Primarily, the disease is often considered as to be an outcome of central sensitization and stress most of the times.
 
 
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