Chelerythrine


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Chel`e`ryth´rine


n.1.(Chem.) An alkaloidal principle obtained from the celandine, and named from the red color of its salts. It is a colorless crystalline substance, and acts as an acrid narcotic poison. It is identical with sanguinarine.
References in periodicals archive ?
In vitro and in vivo activity of protein kinase C inhibitor growth delay in vivo chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
DNA adduct formation from quaternary benzolclphenanthridine alkaloids sanguinarine and chelerythrine as revealed by the P-32-postlabeling technique.
Quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine have been used in folk medicine for their wide range of useful properties.
Chelerythrine (CHE, a PKC inhibitor), 5-hydroxydecanoate (5HD, a selective blocker of mito [K.
12] cells incubated with TGF-[beta]1 in presence or absence of apocynin (NOX inhibitor), SB525334 (TGF-[beta]-receptor I inhibitor), or chelerythrine (PKC inhibitor).
In a similar fashion, isoflurane-mediated mPTP closure was abolished when rats were pre-exposed to the non-selective protein kinase C (PKC) inhibitor chelerythrine and the selective PKC [epsilon]-isoform inhibitor [epsilon]V1-2, but not when pre-exposed to the selective PKC S-isoform inhibitor, rottlerin (22).
Krayacich will be responsible for leading the company's drug and business development for ganaxolone, an adult and pediatric epilepsy candidate in Phase II, and chelerythrine, a pre-clinical schizophrenia candidate.
Structural modification of sanguinarine and chelerythrine and their antibacterial activity.