3] The etiologies of myelopathy were MS, heredodegenerative, systemic lupus erythematosus, electrocution, spinal cord infarction, and clioquinol
Iron is a reactant in the formation of the hydroxyl radical, a highly reactive ROS, via the Fenton reaction, and iron chelating agents, such as clioquinol
(CQ) and deferoxamine, reduced ICH-induced brain edema, neuronal death, and brain atrophy in a rat ICH model [49-51].
Por indicacion del Servicio de Dermatologia se inicia con la administracion de clioquinol
en zonas afectadas y aplicacion de aceite de almendras dulces 2 veces al dia para hidratacion dermica.
2%), while no positive reaction was obtained to clioquinol
and methyldibromoglutaronitrile in any case.
For example, clioquinol
had good activity in guinea pigs but not in mice (Lewis et al.
and docosahexaenoic acid act synergistically to kill tumor cells.
attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice.
Recent animal studies have shown that the drug, clioquinol
, can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases.
Oral treatment of transgenic mouse with clioquinol
resulted in halving of A[beta] levels and significantly increased the levels of Cu and Zn in the brain (72).
fue una droga fabricada en los anos 70 y vendida como un remedio seguro para la diarrea.
The investigators maintain that clioquinol
will target the formation of amyloid plaques in the brain and thereby slow the progression of Alzheimer's disease (AD).
12] were administered to all patients to counteract an observed association between oral clioquinol
and myelooptico-neuropathy that led to the drug's withdrawal from sale in 1970.