Patients were advised tab co-amoxiclav
625mg 8 hourly, tab mefenamic acid 500mg 8 hourly, tab chlorpheniramine maleate 4mg once daily, xylometazoline nasal spray and liquid paraffine nasal drops 2 drops 8 hourly and regular nasal toilet for 5 days.
Oral antibiotic prescribed was co-amoxiclav
, vasoconstrictive nasal spray used was Xylometazoline and local antibiotic ointment prescribed was fucidic acid ointment.
Other antibiotics tested were: imipenem, meropenem, tazobactum, amikacin, cefoperazone sulbactam, gentamicin, cefepime, ceftazidime, co-amoxiclav
, ticarcillin, aztreonam, cefoperazone, co-trimoxazole, cefotaxime, cefixime, ceftriaxone, pipemidic acid and ampicillin.
In this process disc containing co-amoxiclav
was placed at the centre of the plate and cephalosporins were applied edge to edge at the distance of 15mm from the centre disc.
Antibiotics used for sensitivity were co-amoxiclav
, ciprofloxacin, pipemedic acid and co-trimoxazole.
After the surgery, all patients were prescribed an oral antibiotic taken 3 times daily for 5 days after surgery (Augmentin[R] 625 mg Tablets co-amoxiclav
(Amoxicillin and clavulanic acid)) and moxifloxacin 0.
26 So Co-Amoxiclav
is given along with Metronidazole for effective treatment of OMI.
Contract notice: NHS Framework Agreement for the supply of Generic Pharmaceuticals Co-Amoxiclav
and Diamorphine Injection.
A prospective study in 2008, conducted in the medical wards of a tertiary care hospital in Malaysia, found that co-amoxiclav
, erythromycin, cefuroxime, and ceftriaxone, and ampicillin with sulbactam were the most commonly used antimicrobial agents.
Antimicrobial susceptibility testing was performed on Mueller-Hinton agar (Merck, Germany) using disk diffusion (Kirby Bauer's) technique according to Clinical and Laboratory Standards Institute (CLSI) guidelines The following: Cefotaxime 30ig, NalidixicAcid 30ig, Trimethoprim-sulphamethoxazole 30ig, Ceftazidime 30ig, piperacillin-tazobactam , Co-Amoxiclav
10ig, Nitrofurantoin 300ig, Imipenem 10ig, Meropenem 10ig, Ampicillin 30ig, Cefoxitin 30ig, Gentamicin10ig, Cefixime 5ig, Cefepime 30ig, Carbenicillin 100g, Cefprozil 30ig and Tetracycline 30ig.
Moderate levels of resistance were seen to piperacillin-tazobactam (21%), ciprofloxacin (30%), gentamicin (35%) co-amoxiclav
(49%) and the 3rd-generation cephalosporins cefotaxime and ceftazidime (49% and 44%, respectively).
For lactational infections co-amoxiclav
is the drug of choice as it will cover most bacterial infections as well as anaerobes.