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codon |
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The major polymorphisms associated with susceptibility or resistance are located at codons 136 (A or V), 154 (R or H), and 171 (R, Q, of H) (3,4). Biologists have long held that swapping one codon for another doesn't change the resulting protein's structure, as long as both codons instruct the machinery to insert the same amino acid. The sequence of the cloned DNA shows that SeP contains 10 Sec groups encoded by UGA stop codons in the open reading frame of its mRNA (Burk et al. |
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