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1. One of two or more contributing factors.
2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.


1. (Mathematics) maths a number associated with an element in a square matrix, equal to the determinant of the matrix formed by removing the row and column in which the element appears from the given determinant. See minor
2. (Biochemistry) biochem a nonprotein substance that forms a complex with certain enzymes and is essential for their activity. It may be a metal ion or a coenzyme


(ˈkoʊˌfæk tər)

1. a contributing factor.
2. any of various organic or inorganic substances necessary to the function of an enzyme.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cofactor - a substance (as a coenzyme) that must join with another to produce a given result
chemical compound, compound - (chemistry) a substance formed by chemical union of two or more elements or ingredients in definite proportion by weight
References in periodicals archive ?
Human papillomavirus (HPV) is well established as an infection that is central to the pathogenesis of invasive cervical cancer, but because many women with HPV do not develop this cancer, it is believed certain cofactors play a role in disease development.
and GABA itself, along with necessary vitamin and mineral cofactors, can be used to help these problems.
That individually and environmentally mediated cofactors function in the development of infant methemoglobinemia (iMHG) is not a new finding.
Respiratory complexes are macromolecular batteries coupling electron flow through a wire of metal clusters and cofactors with proton transfer across the inner membrane of mitochondria and bacteria.
According to the nonprofit Vitamin D Council, "In order to receive the most health benefit from increased levels of vitamin D, the proper cofactors must be present in the body.
With adjustments made for environmental cofactors, there was a significant correlation between the lifestyle index score and colorectal cancer risk.
Other chapter topics are structure and function of [NiFe]-hydrogenases, carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases, the dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide, copper-carbon bonds in mechanistic and structural probing of proteins, and computational studies of bioorganometallic enzymes and cofactors.
22a), both manganese and magnesium cations are effective cofactors in vitro, but magnesium is the one used in vivo (ref.
Olivamine is a proprietary blend of antioxidants; amino acids and their cofactors, vitamins B6 and B3; and methylsulfonyl-methane.
Crucial steps include identifying infectious etiologies and cofactors, determining persons (including women) at risk for infection or outcome, and implementing measures that minimize chronic sequelae.
Russell and Martin offer yet another piece of circumstantial evidence that life may have emerged from iron sulfide-catalyzed chemistry: Many of the large proteins that drive basic biochemical reactions today--such as ferredoxin, a protein that mediates metabolic reactions--rely on smaller iron sulfur cofactors.
Confirmation of these results, the author argues, will bring about "wider acceptance that high parity and long-term use of oral contraceptives can act as cofactors in the genesis of cervical cancer.