Studies in Asian populations have shown an association between ADH1C alleles and alcoholism, but the protective effect of ADH1C*1 in that population may be explained in large part by its coinheritance
with the ADH1B*2 allele.
Coinheritance of hereditary spherocytosis (HS) and [beta] thalassemia is very rare.
This corollary can be explained by assuming that the coinheritance of [beta]TT with HS probably had an influence on clinical outcome.
6) Other forms result from coinheritance of Hb S with other abnormal [beta]-globin-chain variants.
Coinheritance of alpha-thalassemia-1 and hemoglobin E/beta zero-thalassemia: practical implications for neonatal screening and genetic counseling.
Therefore, SNPs are not randomly sorted along chromosomes; the nonrandom coinheritance
of alleles, which is called LD, tends to be higher among nearby SNPs.
of the HR2 haplo-type in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden).
Interestingly, a case study revealed a significantly higher frequency of coinheritance
of FIFE mutant allele C282Y in patients with XLSA compared to the normal population (57).
of variant MTHFR and MTHFD1 alleles did not have an additive effect on TPMT activity, consistent with reports concluding that MTHFD1 does not directly influence reactions for which a methyl group is required and does not affect SAM concentrations through 5,10-MTHF pools (15).
The identification of genes for complex traits relies on the detection of coinheritance
of chromosomal regions in related individuals or the sharing of functional or marker alleles among phenotypically similar individuals.
of alleles associated with hemochromatosis and hereditary hyperferritinemia-cataract syndrome.
In addition, coinheritance
of the [alpha]-thalassemia gene in [beta]-thalassemia or Hb E also affects their phenotypic expression.