GENESIS will combine these efforts to tackle pertinent questions in this field that could not have been addressed before: We will systematically dissect known nucleic acid sensing pathways in the human system to explore their unique roles, cooperativity
or redundancy in detecting non-self nucleic acids.
This behavior, which is the signature of cooperativity
, is an important feature of the so-called [alpha]-process as studied by TSDC.
Distance constraints between microRNA target sites dictate efficacy and cooperativity
For all levels of platelet count (low, normal, and high), the percentage of samples with the contracted clot signal depended on hematocrit, suggesting cooperativity
between erythrocytes and platelets, perhaps via thrombin generation (20-22).
Hyperglycemia induces a dynamic cooperativity
of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Oocyte regulation of metabolic cooperativity
between mouse cumulus cells and oocytes: Bmp15 and gdf9 control cholesterol biosynthesis in cumulus cells.
of TMPRSS2-ERG with PI3kinase pathway activation in prostate oncogenesis.
Taking the concept of cooperativity
further, the organization of complex genomes takes advantage of additional layers of regulation through which a minor change in one genetic element can broadly influence the expression of many other genes.
You'll think we're always bitching': The Functions of Cooperativity
and Competition in Women's Gossip.
While many complex reaction networks do not satisfy the MM assumptions and hence do not exhibition M-M behavior in their concentration profiles, the M-W-C equation has limitations such as the inability to portray negative cooperativity
among multiple enzyme-substrate systems.
This remarkably high Hill coefficient may imply multiple HXT binding sites exhibiting positive cooperativity
Dudley used antibiotics and related species as vehicles for fundamental thinking about molecular shape and flexibility, and about the thermodynamics of solvation, binding and cooperativity