CoQ10


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CoQ10

abbr.
coenzyme Q10
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Editor's Note: "A recent trial of the oxidized form of CoQ10 for Parkinson's disease failed to show benefits; however, the reduced form of CoQ10 (ubiquinol-10) has shown better neuroprotective effects in animal models," writes author Asako Yoritaka of Japan's Juntendo University and associates.
Underscoring that there is opportunity for market growth with further education of physicians and consumers, the survey also found that 45% of cardiologists without prompting said they recommend CoQ10 to their patients, a rate that is more than double that of other supplements, such as fish oils and vitamins.
Because CoQ10 deficiency can cause various muscle symptoms, it has been suggested that statin-induced myopathy is due in part to CoQ10 deficiency.
The human body produces its own CoQ10 but with age and medication, CoQ10 levels diminish, particularly with cholesterol-lowering statin drugs.
CoQ10 promotes cardiovascular health in part by confronting oxidative stress, thereby supporting healthy blood vessels and circulation.
Patients with primary and secondary CoQ10 deficiency have been reported (4, 8-12).
The Q-SYMBIO study (2) randomised 420 patients with severe heart failure (New York Heart Association (NYHA) Class III or IV) to CoQ10 or placebo and followed them for 2 years.
0 from baseline, and CoQ10 significantly reduced serum PSA by 33.
How might CoQ10 help patients affected by genetic mitochondrial diseases?
Although the benefits of CoQ10 have long been established, the main challenge that stands before the nutraceutical industry is getting this highly sought after molecule into the body.
Since grapefruit juice is reported to inhibit P-gp function, this study investigated the effect of the juice on the transport of CoQ10 by Caco-2 cells (a cell line used to model the lining of the human intestine).