Nasdaq symbol: NTII) announced today the results of a pilot Phase I/II trial of Corticotropin-Releasing Factor
(CRF) for the treatment of rheumatoid arthritis.
Over the next several months, we expect to report on the trial results of our lead drug candidate, Corticotropin-Releasing Factor
(CRF), in rheumatoid arthritis, asthma, and brain edema, and to proceed to more extensive efficacy trials for one or more of these indications.
The federally funded study showed how a stress receptor, known as corticotropin-releasing factor
, or CRF1, can send signals to certain immune cells, called mast cells, and control how they defend the body.
Insulin-induced hypoglycemia stimulates corticotropin-releasing factor
and arginine vasopressin secretion into hypophysial portal blood of conscious, unrestrained rams.
However, due to elevated levels of plasma cortisol, corticotropin, and corticotropin-releasing factor
during pregnancy, this is not the method of choice in pregnancy.
Instead, increased neuronal activity was driven by a stress hormone, corticotropin-releasing factor
(CRF) and its type 1 receptor (CRF1) Blocking CeA CRF1 reduced voluntary alcohol intake in the dependent rats.
An important modulator is the serotonergic system, controlling HPA axis function on at least two levels: on one hand, activating the corticotropin-releasing factor
(CRF) and secondly, by regulating cortisol and CRF activity at the synaptic level (Drabant et al.
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Heilig M, Koob GF Ekman R, Britton KT Corticotropin-releasing factor
and neuropeptide Y: role in emotional integration.
Physiological and behavioral responses to corticotropin-releasing factor
administration: is CRF a mediator of anxiety or stress responses?
Furthermore, the serotonergic, noradrenergic, corticotropin-releasing factor
and cannabinoid systems seem to play an important role in the neurobiology of alcoholism.
One of the most important discoveries in the last decade in identifying the substances related to stress response is a family of peptides named corticotropin-releasing factor
(CRF): urocortin 1, urocortin 2, and urocortin 3.