The first study comprised 32 healthy subjects in whom itch was induced with cowhage
before and after skin treatment with the strontium gel, a control vehicle, topical 1% hydrocortisone, and topical 2% diphenhydramine (Acta Derm Venereol.
John's wort, changes induction of echinacea, ginkgo, cytochrome P450 garlic, grapefruit, enzymes goldenseal, resveratrol Changes in Increased diuresis Dandelion, yerba mate, elimination or fluid retention stinging nettle, cowhage
Pharmacodynamic Supplement has Anticonvulsants: ginkgo interactions either similar or (may lower seizure opposing effects threshold) to target drug Antihypertensives: yohimbe (could increase blood pressure) CNS depressants: valerian (GABA agonist)
Yosipovitch and colleagues induced itch on the ankles, forearms and backs of 18 study participants with cowhage
spicules, which come from a type of legume found in tropical areas that are known to cause intense itching.