Cox-2 inhibitor


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COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
sup][2] In the present case, the prothrombotic effect of a selective COX-2 inhibitor might not be the main pathophysiology of MI.
But if you're at risk for a blood clot (thrombosis) in a deep vein, you may want to think twice about a particular painkiller: a COX-2 inhibitor (Celebrex[R]).
The results showed that of those currently using a COX-2 inhibitor, 19% were more likely to die after a stroke than those who didn't take the drug and new users of the medicines had a 42% increase in risk mortality from stroke compared to nonusers.
In contrast studies conducted prior to rofecoxib withdrawal showed high prevalence of selective COX-2 inhibitor prescription, like Study in Calicut showed upward trend in prescription of selective COX-2 inhibitor during the year 2000 to 200320.
Researchers noted the increase in fall-related injuries began in 2004, when the drug Vioxx, a COX-2 inhibitor widely prescribed for arthritis pain, was taken off the market because of its link to a higher risk of heart attacks and strokes.
Researchers noted the increase in fail-related injuries began in 2004, when the pain killer rofecoxib (Vioxx), a COX-2 inhibitor widely prescribed for arthritis pain, was taken off the market because of its link to a higher risk of heart attacks and strokes.
M2 PHARMA-December 29, 2011-RaQualia teams up with Chinese partners for COX-2 inhibitor development(C)2011 M2 COMMUNICATIONS
In particular, we will examine the impact of DTCA on the time patients wait after diagnosis with OA and before initiating treatment with a COX-2 inhibitor.
More specifically, the impact of the PAR for COX-2 inhibitors on total prescription costs for recipients who switched from a COX-2 inhibitor to an NSAID or other pain relievers was analyzed.
Celecoxib is the only COX-2 inhibitor available, and it is associated with a lower risk of renal dysfunction and hypertension when compared with controls.
To test whether thwarting COX-2 would have an effect on mice predisposed to pancreatic cancer, the researchers fed chow containing a COX-2 inhibitor called nimesulide to mice harboring the Kras mutation.
26 in the journal Circulation, the American Heart Association (AHA) cautions doctors about recommending the COX-2 inhibitor celecoxib (Celebrex), and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit this enzyme.