Cox-2 inhibitor


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COX-2 inhibitor

n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
The results showed that of those currently using a COX-2 inhibitor, 19% were more likely to die after a stroke than those who didn't take the drug and new users of the medicines had a 42% increase in risk mortality from stroke compared to nonusers.
In particular, we will examine the impact of DTCA on the time patients wait after diagnosis with OA and before initiating treatment with a COX-2 inhibitor.
More specifically, the impact of the PAR for COX-2 inhibitors on total prescription costs for recipients who switched from a COX-2 inhibitor to an NSAID or other pain relievers was analyzed.
To test whether thwarting COX-2 would have an effect on mice predisposed to pancreatic cancer, the researchers fed chow containing a COX-2 inhibitor called nimesulide to mice harboring the Kras mutation.
Green tea alone reduced tumor growth by 42%, and the Cox-2 inhibitor celecoxib slowed it by 57% on its own, according to a study published in last week's issue of the journal Clinical Cancer Research.
Selective COX-2 inhibitors have been in the news since the FDA removed the selective COX-2 inhibitor, rofecoxib, from the market in 2004.
Vioxx, a COX-2 inhibitor in anti-inflammatories, was banned in 2004 after it was shown that patients on the drug were more than twice as likely to have heart attacks as those not taking it.
Three studies of COX-2 inhibitors have shown that administration of a COX-2 inhibitor is associated with a reduction in polyps in high-risk patients.
Research has found that the Cox-2 inhibitor celecoxib, which is used to treat arthritis and acute pain, increases by more than twofold the risk of a heart attack.
Don't write off the entire COX-2 inhibitor class of drugs, says Dr.
A total of 40, 000 were given another Cox-2 inhibitor, Celebrex, while others were taking ibuprofen or naproxen.
Celebrex was the first COX-2 inhibitor, a class of medicine designed to