Rash, diarrhea, fatigue, and increased blood creatine phosphokinase
were the most frequent treatment-related grade 3-4 AEs reported (five% each).
Results of blood tests showed severely elevated creatine Phosphokinase
(CPK) and aspartate aminotransferase (AST) activities, confirming suspected capture myopathy.
In addition, CK-MM along with the mitochondrial creatine Phosphokinase
isoform is involved in the transport of energy to muscular contraction proteins (8, 9).
Symptoms included fever, altered level of consciousness, changes in mental status, drooling, diaphoresis, urinary incontinence, sweating, development of tremors, lead pipe rigidity, tachycardia, and increased level of creatine phosphokinase
7 (below 5 mg/l), aspartate aminotransferase (AST) 572 (below 37 U/l), alanine transaminase (ALT) 130 (below 40 U/l), lactate dehydrogenase (LDH) 1684 (460 U/L and creatine phosphokinase
(CPK) 19344 (below 171 U/l), and after basic diagnostic procedures were performed, intravenous hydration and antibiotic therapy (ceftriaxone, amikacin) were initiated.
The most common adverse events were diarrhea, occurring in 7% of daptomycin patients and 5% of SOC patients; and increased creatine phosphokinase
, occurring in 6% of daptomycin patients and 5% of SOC patients (Pediatrics.
The results revealed that administration of EESR to rats pre-irradiation significantly reduced the severity of radiation-induced elevation of tumor necrosis factor a, interleukin 1b, interleukin 6 and serum creatine phosphokinase
, lactate dehydrogenase and aspartate amino transferase activities, total cholesterol and low-density lipoprotein-cholesterol levels, high-density lipoprotein-cholesterol, creatine kinase-MB and cardiac troponin 1.
Side effects included increased blood creatine phosphokinase
, myalgia and anaphylactic reactions.
Biochemical parameters like SGOT, SGPT, creatine phosphokinase
, lactate dehydrogenase were markedly raised in the insecticide exposed agriculture workers as compared to control group.
62 g/L, creatine phosphokinase
(CPK) 2300 U/L, alanine aminotransferase 180 U/L, aspartate aminotransferase 265 U/L, pH 7.
Serum uric acid (UA), creatine phosphokinase
and urinary malondialdehyde (MDA) were evaluated.
Adverse events (AEs) leading to withdrawal during the oral phase (7/105) included three events of neutropenia, three events of increasing blood creatine phosphokinase
(CPK) and one event of fatigue.