NC381 has demonstrated in pre-clinical studies to preferentially inhibit the synthesis of growth regulating proteins called cyclins
by depleting calcium supplies in tumor cells.
The study was conducted to further investigate prior indications of the drug's ability to perturb cell cycle progression, focusing on the patterns of expression of cyclins
and inhibitors of CDKs.
In particular, CLT inhibits translation initiation and thereby accumulation of proteins such as cyclin
D1, E and A, called G1 cyclins
, that promote cell growth in the G1 phase of the cell cycle.
The major molecular players in cell-cycle progression include Cdks, cyclins
, the retinoblastoma (RB) tumor suppressor gene product and the E2F transcription factor family and associated proteins (Buolamwini, 2000).
I am delighted that the citation of the 2001 Nobel Prize in Medicine pays tribute to the importance of CDKs and cyclins
and their role in checkpoint control of cancer cells.
Overexpression of mouse D-type cyclins
accelerates G1 phase in rodent fibroblasts.
-dependent kinases play an important role in regulation of the cell cycle (Sherr 1996).
The accumulation and breakdown of cyclins
is an essential step in cell division.
1]-S check-point is mainly regulated by a series of cyclins
-dependent kinase (CDK), which predominantly are cyclinD/[CDK.
barbata extract caused apoptosis and decreased the expression of cyclins
-dependent kinases (Kim et al.
-dependent kinases, and tumor suppressor gene products interact and regulate the normal cell cycle.
This enzyme and others like it link up with proteins called cyclins
, and together these molecules push a cell to start dividing.