cyclooxygenase

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Related to Cycloxygenase: Cyclooxygenase 2 inhibitors

cy·clo·ox·y·gen·ase

 (sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Cox-1, cyclooxygenase-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"
Cox-2, cyclooxygenase-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"
References in periodicals archive ?
Cycloxygenase 2 (Cox 2) inhibitors and/or bisphosphonates have shown some improvements.
14 CLA has anti-inflammatory properties via inhibiting of cycloxygenase (COX) and lipoxygenase (LOX) messenger ribonucleic acid (mRNA) expression and can bind to and activate the peroxisome proliferator-activated receptor gamma (PPARY).
laevifrons, suggest a presence of two muscarinic receptors of high and low sensibility to acetylcholine and a coupled mechanism between muscarinic receptors and vasoconstriction mediated by cycloxygenase (Moraga and Urriola-Urriola, 2014).
43] The mechanism of the protective effect of DPA on prostate cancer may be explained by biochemical processes involving: reduced prostacyclin production, expression of inflammatory genes and TNF-induced necrotic cell death; competition with cycloxygenase 2 (COX2) enzymes resulting to anti-neoplastic activity via proapoptotic pathway; and inhibition of angiogenesis.
The precursor, for PGs is arachidonic acid, which is metabolized by cycloxygenase (cox) enzymes resulting in its production.
There are many studies regarding the anti-inflammatory activity of plants is produced by phenolics and flavonoids as carvacrol, the flavones genkwarin and luteolin and the 6-hydroxy flavones cirsimaritin and salvigenin and polyphenolics as rosmarinic acid, and the monoterpenoid present in the essential oil: [alpha]-pinene (that inhibit the enzyme cycloxygenase and weak selectivity for eicosanoid, leukotriene B4 [LTB4] that was measured by radio immunoassay) and geraniol show weak selectivity for the thromboxane B2 [TXB2].
The pathophysiology of septic shock is complex, involving multiple endogenous mediators as cytokines, nitric oxide (NO), and cycloxygenase 2 (COX2).