Altepan is a monoclonal antibody targeting members of the cysteinyl
leukotriene family, which are important mediators of inflammatory disorders.
Like zafirlukast, montelukast is a competitive antagonist for the cysteinyl
blocking of the histamine H1 receptors, but sometimes additional help is obtained from blockers of the cysteinyl
Montelukast is a CysLT1 antagonist that blocks the action of leukotriene D4 on the cysteinyl
leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it.
Effects of a cysteinyl
leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis.
In sections on general aspects, drug classes, and case studies, they explore such topics as competition in pharmaceutical drug development, using macrocycles in drug design exemplified by a potential ghrelin agonist for gastrointestinal motility disorders, the development of cysteinyl
luekotriene receptor antagonists, from morphine and tramadol to the discovery of tapentadol, and a case study for the role of structure-based drug design.
They secrete a variety of inflammatory mediators, including histamine, proteases, prostaglandins and cysteinyl
003) on caspase 14, a cysteinyl
aspartate-specific protease, activated during terminal differentiation of the epidermis.
Pulmonary production of soluble mediators PGE(2), LTB(4) and cysteinyl
leukotrienes, and nasal expression of IL-4, -5, -13 and IFN-gamma were also inhibited by gammaT.
27-29) One LOX enzyme in particular, 5-LOX, has been implicated in the production of the highly inflammatory cysteinyl
leukotrienes and leukotriene (LT[B.
The NSAID intolerance is believed to be non--IgE-mediated and occurs due to shunting of the arachidonic pathway by cyclooxygenase-1 inhibition with overproduction of cysteinyl
leukotrienes and release of inflammatory mediators, including histamine and tryptase, from mast cells and eosinophils.
Albumin oxidation to diverse radicals by the peroxidase activity of Cu, Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl
and solvent-exposed and -unexposed tyrosyl radicals.