cytochalasin

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cytochalasin

(ˌsaɪtəʊkəˈleɪsɪn; ˌsaɪtəˈkæləsɪn)
n
any of a group of metabolites derived from fungus that interfere with cell processes
References in periodicals archive ?
Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.
The cytochalasins are a group of toxic fungal metabolites which show marked cytotoxic effects on mammalian cells in tissue culture.
Cytochalasins and Phytotoxins from the fungus Xylaria obovata.
1973); by the fertilization modifications of microfilament distribution, particularly in fertilization cones (Longo, 1978b, 1980; Tilney and Jaffe, 1980; Schatten and Schatten, 1980; Cline and Schatten, 1986); and by the blockage of fertilization by the inhibition of microfilament polymerization using cytochalasins (Gould-Somero et al.
The company also has patents relating to the biological stenting of traumatized blood vessels by administration of cytoskeletal inhibitors such as cytochalasins (Biostent(R) therapy).
Four cytochalasins, termed phomachalasins A-D (11-14), were isolated and characterised as three closely related 26- oxa[16] and one new[15] cytochalasan.
The cytochalasins are a group of toxic fungal metabolites which exhibited a broad spectrum of biological activity including antibiotic and antitumor activity (Katagiri and Matsura 1971), inhibition of HIV-1 protease (Wells et al.
Apoptosis induction in HCT116 cells by cytochalasins isolated from the fungus Daldinia vernicosa.
2004) isolated two phytotoxic compounds namely cytochalasin B and dihydrocytochalasins from culture filtrates of D.
Early studies also demonstrated that growth cone motility depends on actin filament assembly (Yamada and Wessells, 1973), and a critical role for actin assembly in axonal guidance emerged when axons in the developing grasshopper nervous system were shown to lose all path-finding capabilities upon treatment with cytochalasin (Bentley and Toroion-Raymond, 1986).