NeuroRx is developing a sequential treatment regimen of NRX-100 (ketamine) and NRX-101, a proprietary formulation of d-cycloserine
/ lurasidone, for the treatment of severe bipolar depression in patients with acute suicidal ideation and behavior.
The company said NRX-101 is a patented, oral, fixed-dose combination of two US FDA-approved drugs: d-cycloserine
, a N-methyl-D-aspartate (NMDA) receptor modulator, and lurasidone, a 5-HT2a receptor antagonist.
They also found the quality of evidence to be very low for the drug class of benzodiazepines and four drugs--risperidone, D-cycloserine
, ketamine, and hydrocortisone.
The remission rate was 60% at 3 months follow-up post I-CBT in antidepressant-free patients on D-cycloserine
, compared with just 24% in D-cycloserine
recipients taking antidepressants during I-CBT.
sup] We recently observed clinical improvement in one refractory case with anti-NMDAR encephalitis after administration of D-cycloserine
Rather, drugs can be used to make the exposure treatment more effective (the pharmaceutical d-cycloserine
has shown some promise in this regard).
Materials and Methods: Antituberculosis drug susceptibility testing of 50 MDR-TB isolates particularly for SLDs, namely p-aminosalicylic acid, ciprofloxacin, amikacin, d-cycloserine
, kanamycin, and ethionamide, was conducted on solid Lowenstein-Jensen medium using the 1% proportion sensitivity method.
For example, D-cycloserine
, a glycine-site partial agonist, has been shown in several studies to enhance learning and behavioral therapies in anxiety disorders.
Arbaclofen, intranasal oxytocin, and D-cycloserine
for the treatment of core deficits in autism spectrum disorders are all moving forward to more advanced clinical trials on the basis of encouraging studies highlighted at a meeting of the New Clinical Drug Evaluation Unit sponsored by the National Institute of Mental Health.
110-113] Furthermore, D-cycloserine
reverses fear extinction deficits caused by stress and other factors, [114,115] blocks the extinction-impairing effect of the corticosteroid synthesis inhibitor metyrapone, and enhances the extinction-facilitating effects of the synthetic glucocorticoid dexamethasone.
The medication used, D-Cycloserine
, originally was developed to treat tuberculosis, but previous studies showed, by chance, that it might change social behavior.
The one that I'm referring to is a drug called d-cycloserine