Results: Treatment with esculin, scoparone and daphnetin produced the best protective effects.
Discussion: The intestinal anti-inflammatory activity of coumarin derivatives were related to their antioxidant properties, suggesting that consumption of coumarins and/or foods rich in coumarin derivatives, particularly daphnetin, esculin and scoparone, could prevent intestinal inflammatory disease.
Scopoletin (6-methoxy-7-hydroxycoumarin), scoparone (6,7-dimethoxy-coumarin), fraxetin (7,8-dihydroxy-6-methoxycoumarin), 4-methylumbelliferone (4-methyl-7-hydroxycoumarin), esculin (6,7-dihydroxy-6-0-glucosylcoumarin), daphnetin (7,8-dihydroxycoumarin) (Fig.
Natural products like esculetin, fraxetin, daphnetin
and other related coumarin derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase enzymic systems, and of neutrophil-dependent superoxide anion generation (Fylaktakidou et al.