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It is a distant relative of daptomycin, a powerful antibiotic that uses calcium to disrupt bacterial cell walls.
8) Currently, the therapeutic options approved by Food and Drug Administration (FDA) for the SSTIs by MRSA include daptomycin, linezolid, and the recently introduced, tedizolid.
DAPTOMYCIN WAS SAFE and effective at treating complicated skin and skin structure infections (cSSSI) in children aged 1-17 years, according to John Bradley, MD, of the University of California, San Diego, and his associates.
A total of 389 patients with cSSSI were included in the study, with 257 receiving daptomycin and 132 receiving standard-of-care (SOC) treatment (mostly vancomycin or clindamycin).
The company said Daptomycin for injection is an antibacterial drug indicated in adults for the treatment of complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive bacteria: Staphylococcus aureus (including methicillin-resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subspecies equisimilis and Enterococcus faecalis (vancomycin-susceptible isolates only).
We conducted a prospective, observational, multicenter study during April 2011-June 2014 in 5 hospitals in Spain in which we included patients given a diagnosis of MSSA CRBSI according to standard a definition (14) that fulfilled 5 criteria: 1) age [greater than or equal to] 18 years and a life expectancy [greater than or equal to] 7 days; 2) no use of daptomycin within the 3 months preceding the incident MSSA CRBSI episode; 3) removal of the intravascular catheter suspected to be the source of CRBSI within a maximum of 72 hours from sampling of the first blood cultures yielding MSSA; 4) a maximum of 72 hours of treatment with glycopeptides; and 5) at least the first blood culture isolate available for microbiological analysis.
1) Daptomycin is a cyclic lipopeptide antibiotic derived from Streptomyces roseosporus, which shows a potent bactericidal activity against most Gram-positive organisms including MRSA.
DENVER -- In obese patients with vancomycin-resistant enterococcal bacteremia, using a dose of daptomycin based on adjusted body weight rather than actual body weight resulted in similar efficacy and outcomes.
2 ( ANI ): Researchers have identified a novel mechanism that a particular superbug uses to fight off a key front-line antibiotic called daptomycin.
SAN FRANCISCO--Standardized, low-dose daptomycin is safe and effective for treating gram-positive urinary tract infections, a small observational study demonstrated.
CHICAGO - Daptomycin works as well at clearing diabetic skin and soft tissue infections in real-world clinical practice as it does in clinical trials, according to a retrospective analysis of data from a large European registry.
New data on at-home infusion of daptomycin compared to vancomycin are presented.
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