darunavir


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Related to darunavir: Raltegravir
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darunavir

n darunavir m
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Building on a decade-long partnership, Janssen Sciences Ireland UC granted IPM an exclusive, royalty-free license to develop its HIV medicine and commercialize in a number of developing countries its HIV medicine darunavir as a potential vaginal and rectal microbicide for HIV prevention in women.
We also thank Hermien Gous and Angela Oosthuizen for organising the darunavir and for adherence counselling, Gert van Zyl and his laboratory at Stellenbosch University for genotyping, Shobna Sawry for Therapy Edge access, and Merleesa Govender for the MCC applications.
The study participants received 600 mg of darunavir and 100 mg of ritonavir twice daily.
18) No one had tried darunavir, and no one had a record of virologic failure.
Both the ARTEMIS and the CASTLE studies suggest that in PI-naive patients, both atazanavir and darunavir can be boosted with 100 mg of ritonavir, which is an advantage.
Prezista (also called darunavir, or TMC-114), a new protease inhibitor active against many of the viruses resistant to other protease inhibitors, was approved by the FDA on June 23 "for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.
The Pharmacor advisory service entitled Human Immunodeficiency Virus (HIV) finds that the primary factor constraining the HIV therapy market is the generic erosion of numerous commonly prescribed ARV drugs, such as efavirenz (Bristol-Myers Squibb's Sustiva, Merck/Banyu's Stocrin), tenofovir (Gilead/Japan Tobacco's Viread), atazanavir (Bristol-Myers Squibb's Reyataz), darunavir (Janssen's Prezista), emtricitabine/tenofovir (Gilead/Japan Tobacco's Truvada), efavirenz/emtricitabine/tenofovir (Gilead/ Bristol-Myers Squibb's Atripla) and lopinavir/ritonavir (Abbott's Kaletra).
Once-daily dolutegravir versus darunavir plus ritonavir for treatment-naive adults with HIV-1 infection (FLAMINGO): 96 week results from a randomised, open-label, phase 3b study.
The 2008 IAS-USA guidelines (8) for initial antiretroviral therapy recommend either of two basic three-drug regimens: efavirenz plus two NRTIs, or a ritonavir-boosted protease inhibitor (lopinavir, atazanavir, fosamprenavir, darunavir or saquinavir) plus two NRTIs.
The combination of tenofovir plus emtricitabine is the current "backbone" pairing, with abacavir plus lamivudine as the major alternative; recommended third agents are efavirenz, atazanavir, darunavir, or raltegravir.
The new regimen consisted of ritonavir-boosted darunavir and Trizivir (abacavir, lamivudine and zidovudine).