GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: Effects on nitric oxide synthase activity, protein levels and dimerisation
These monomer subunits are bonded by disulphide-linkage by dimerisation
, thus producing a 140-kDa dimer.
This has also being observed with anthraquinones, as it was shown that the dimerisation
of anthraquinone 3-hydroxy-2-hydroxymethylanthraquinone (m/z: 254) leading to schimperiquinone B (m/z: 460) significantly reduced the degree of activity towards cancer cells tested in the present work (Kuete et al.
In people with Stargardt's, toxic clumps can form from vitamin A through a process called dimerisation
, which had been suggested as a cause of the disease.
Loss of dimerisation
of the nonstructural protein NS1 of Kunjin virus delays viral replication and reduces virulence in mice, but still allows secretion of NS1.