a.1.(Mach.) Acting directly, as one part upon another, without the intervention of other working parts.
Direct-acting steam engine
one in which motion is transmitted to the crank without the intervention of a beam or lever; - also called direct-action steam engine.
Direct-acting steam pump
one in which the steam piston rod is directly connected with the pump rod; - also called direct-action steam pump.
References in periodicals archive ?
The Humphrey 315/415 Series direct-acting solenoid valves are only 19 mm-wide, yet have a 0.
Engineered for handling corrosive fluids by isolating all metal components from the operating media, the three-way, normally closed, direct-acting diaphragm solenoid design, combined with a compact size and low internal volume, make the units suitable for rigorous applications in a range of analytical and clinical instrumentation.
It was reported yesterday that Idenix Pharmaceuticals, a United States-based biopharmaceutical company, has commenced patient enrolment in the Phase II HELIX-2 clinical trial assessing an all-oral, direct-acting antiviral HCV combination therapy of samatasvir, simeprevir and TMC647055 for the treatment of hepatitis c virus.
It was reported yesterday that the collaboration is aimed at commencing a Phase IIa trial of an interferon-free, direct-acting antiviral combination treatment for patients with chronic hepatitis C virus infection.
The collaboration is aimed at the clinical development of direct-acting antiviral hepatitis C virus combination therapies, retaining all rights to their respective compounds.
The company said its direct-acting antiviral, ANA598, is being tested in both treatment-naive patients and patients who failed a prior course of HCV therapy with interferon and ribavirin.
8 November 2011 - Bristol-Myers Squibb (NYSE:BMY) unveiled on Monday results from its ongoing Phase II study of the treatment with a dual, all-oral direct-acting antiviral (DAA) regimen of the investigational NS5A replication complex inhibitor daclatasvir (BMS-790052) and the investigational NS3 protease inhibitor asunaprevir (BMS-650032).
Biopharmaceutical company Anadys Pharmaceuticals Inc (Nasdaq:ANDS) revealed on Tuesday the initiation of its Phase IIb study of ANA598, a direct-acting antiviral or DAA, in combination with pegylated interferon and ribavirin for the treatment of hepatitis C.
8 September 2011 - US biopharmaceutical company Gilead Sciences Inc (NASDAQ:GILD) said it would stop the dosing of GS 9190 in hepatitis C-infected patients, participating in its clinical trials, who are treated with it in combination with pegylated interferon and ribavirin, and another direct-acting antiviral agent.
These data support the evaluation of direct-acting antiviral (DAA) combination regimens for the treatment of HCV, the company said.
M2 PHARMA-April 1, 2011-Bristol-Myers Squibb reports Phase II study data for direct-acting antiviral BMS-790052 in hepatitis C patients(C)2011 M2 COMMUNICATIONS
ANA598 is the company's direct-acting antiviral, or DAA, being developed for the treatment of hepatitis C.

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