In Alzheimer's disease (AD), disturbances in the dopaminergic system
may explain the high comorbidity of apathy, which ranges from 47% in mild AD to 80% in moderate AD.
The augmented activity of the dopaminergic system
in response to exercise initiation appears to be due to an increase in the central levels of calcium, which increases the activity of tyrosine hydroxylase through the activation of the calcium-calmodulin system (64).
10] The mPFC is mainly innervated by dopaminergic nerve fiber projections from the VTA and forms the midbrain cortex dopaminergic system
, which controls recognition and thinking ability.
Caffeine increases dopamine levels by slowing down the rate of dopamine reabsorption, and this dysfunction of the dopaminergic system
is thought to explain part of the association between caffeine consumption and offspring behavioral disorders," the investigators said.
This article summarizes the current evidence for the involvement of the dopaminergic system
for PSD, using both preclinical and clinical models.
Therefore, leptin was shown to be able to modulate the mesolimbic dopaminergic system
Characterize the molecular physiology of glucose sensing neurons of the paraventricular thalamus, which modulate the activity of the mesolimbic dopaminergic system
to control motivated sucrose-seeking behavior; determine their control by other interoceptive signals, including from glucose sensing cells of the VMN.
Specific drugs noted include those affecting the dopaminergic system
, valproic acid, and medications that elevate prolactin.
In fact, most depression and mental illness is preventable at the source by giving babies and children continual warmth and kindness in securely attached low-stress childhoods (thus allowing proper formation of the brain's dopaminergic system
which regulates self-soothing), along with proper nutrition, sleep, nature, free play, and protection from screen media that stupefies and sells addiction to junk food, outer beauty, premature sexuality, gaming and pornography.
This supports the hyperactivity-model of feather pecking, suggesting that feather pecking is related to a higher general activity, possibly due to changes in the dopaminergic system
Changes in neurochemical transmission within the dopaminergic system
, especially through dopamine D2 receptors are of critical importance for both emergence of schizophrenia and its current treatment with antipsychotic drugs [7, 8].
Subsequently, the responsible mesolimbic dopaminergic system
may also degenerate later than the nigrostriatal system.