dysbindin


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dysbindin

(dɪsˈbɪndɪn)
n
(Genetics) a gene associated with schizophrenia
[C20: from dys(trobrevin-)bind(ing) (prote)in]
References in periodicals archive ?
The susceptibility genes with the strongest evidence are dystrobrevin binding protein 1 or dysbindin (DTNB1) and neuregulin 1 (NRG1).
Arnold, MD, director of the Penn Memory Center, used a mouse with a mutated dysbindin gene to understand how reduced dysbindin protein may cause symptoms of schizophrenia.
They discovered how a specific set of nerve cells that control fast brain activity lose their effectiveness when dysbindin protein levels are reduced.
Other previous work at Penn in the lab of Michael Kahana, PhD has shown that in humans the fast brain activity that is disrupted in mice with the dysbindin mutation is also important for short-term memory.
We know that in schizophrenia this ability is reduced, and now, knowing more about why this happens may help explain how loss of a protein called dysbindin leads to some symptoms of schizophrenia.