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efferent |
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| Several reasons explain the poor prognosis associated with mucosal melanoma: (1) the nonspecific nature of its symptoms leads to delays in diagnosis, (2) the tumor affects many older people whose immune function is inefficient, (3) the rich vascular and lymphatic efferents of the mucosa favor early metastasis, and (4) mucosal melanoma is histologically aggressive. Delayed bradycardia in these animals is triggered by direct vagal nerve inputs to the heart, which would arise from the activation of cholinergic vagal efferents of the parasympathetic nervous system. 25-28) In its conventional form, TENS has been shown to selectively activate large-diameter A[beta] fibers without concurrently activating small-diameter A[delta] and C-fibers or muscle efferents, which leads to inhibition of ongoing activity in second-order nociceptive neurons. |
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