2], is metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) to lipid mediators including prostaglandins (PGs) and leukotrienes (LTs), which are often referred to as eicosanoids
The first phase is mediated through the release of histamine, serotonin, and kinins whereas, the second phase is known to be influenced by the lipid-derived eicosanoids
(prostaglandins, leukotrienes, etc.
In in-vivo experimentally-induced inflammatory reaction in rats, bromelain was tested for its action on eicosanoids
Mechanical stimulations result in a release of cell mediators, such as histamine, eicosanoids
, and cytokines, that causes the associated symptoms.
Editor's Note: "Several arachidonic acid-derived eicosanoids
exert their significant influence on the inflammatory response," write the authors.
Various markers of airway inflammation and oxidative stress such as cytokines, eicosanoids
, nitric oxide, urates, and hydrogen peroxide have been shown to be increased in EBC of patients with asthma.
11,12,13) Short chain EFA-Omega (6) (Linoleic Acid) and Omega 3 (Alpha linolenic acid) with the help of enzymes desaturase and elongase are converted to Long Chain Fatty Acids, AAArachidonic Acid, GLA-Gamma linolenic acid, DGLA-DihomoGLA, EPA-Eicosapentaenoic Acid, DHA- Docosahexaenoic Acid which are further converted to eicosanoids
(PGProstaglandins, PGI-Prostacyclins, TX-Thromboxane by the enzyme Cyclooxygenase and LT-Leukotrienes by the enzyme15-Lypoxygenase).
2010), of which responses are closely linked to eicosanoids
It is designed to trigger the production of "Specialized Pro-resolving Lipid Mediators" that activate an endogenous cascade responsible for the resolution of inflammation and fibrosis, while reducing production of pro-inflammatory eicosanoids
and cytokines, concluded the company.
Each chapter addresses one of seven major lipid classes--fatty acids, eicosanoids
and bioactive lipid mediators, fatty acyl esters and amides, glycerol esters, glycerophospholipids, sphingolipids, and steroids--with details on the pathways of formation of major product ions and ions used for structural characterization.
This phenomenon is believed to be related to increased progesterone (11, 12), enhanced production of nitric oxide (NO), endothelin-I and eicosanoids
The administration of prostaglandin synthesis inhibitors is considered a pharmacological tool to prevent the endogenous release of these eicosanoids
during the maternal recognition of pregnancy (Scenna et al.