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epitope
(redirected from Epitopes)

    Also found in: Medical, Encyclopedia, Wikipedia 0.09 sec.
ep·i·tope  (p-tp)
n.
A localized region on the surface of an antigen that is capable of eliciting an immune response and of combining with a specific antibody to counter that response.
[epi- + Greek topos, place, spot.]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
antigenic determinant, determinant
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)


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? Mentioned in ? References in periodicals archive
 
Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels.
Detecting hepatitis B surface antigen mutants by Coleman, Paul F. / Emerging Infectious Diseases
The linear IgE-binding epitopes of the Ara h2 allergen have been mapped using overlapping peptides and serum IgE from a population of patients known to be sensitized to peanuts.
Protein digestibility and relevance to allergenicity. (Genetically ... by Hinton, Dennis M. / Environmental Health Perspectives
A useful approach may involve the use of an expression library, whereby the genome of a pathogen is fragmented and the pieces of DNA captured to create a pathogen library that represents most of the T cell epitopes that exist for that pathogen.
Generation of multivalent genome-wide T cell responses in HLA-A*0201 ... by Barry, Michael A. / Research Initiative/Treatment Action!
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