GTEx was unique because its researchers explored how genomic variation affects the expression of genes
in individual tissues, across many individuals, and even within an individual, said Simona Volpi, Ph.
The findings showed that just a single session of endurance exercise - activities that increase breathing and heart rate such as walking, jogging, swimming - increased the expression of genes
that are used to repair damaged DNA and helped remodel heart tissue.
Furthermore, Quantitative reverse transcription PCR was proved to eliminate the false positive rate to validate effectively the differential expression of genes
The current findings show that IMP1 inhibits the expression of genes
that trigger stem cells to commit to specific fates, while promoting the expression of genes
related to self-renewal.
These results provide an initial step toward the improvement of lung cancer therapy that is based on measurement of the expression of genes
in the metastatic lymph nodes.
Also, MN-001 has been shown to down-regulate expression of genes
that promote fibrosis including LOXL2, Collagen Type 1 and TIMP-1, down-regulate expression of genes
that promote inflammation including CCR2 and MCP-1, reduces fibrosis in multiple animal models and is generally safe and well-tolerated, concluded the company.
The specific signature results from a chemical modification of DNA called methylation, which can control the expression of genes
like a dimmer on a light switch.
2004) also reported that nutrition restriction increased the expression of genes
for substrate (protein, lipid) turnover, but decreased that of the genes modulating skeletal muscle growth.
Gal4 is used to control the ectopic expression of genes
The study shows that even small, tissue-specific changes in the expression of genes
can have noticeable morphological effects.
FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes
involved in cell growth, proliferation, differentiation, and metabolism.
Michael Holick, concluded that, "Our data suggest that any improvement in vitamin D status will significantly affect expression of genes
that have a wide variety of biologic functions of more than 160 pathways linked to cancer, autoimmune disorders, and cardiovascular disease, which have been associated with vitamin D deficiency.