Objective: Originally described by cytogeneticists, common fragile sites (CFSs) are chromosomal regions known for their susceptibility to break and rearrange aberrantly, thus altering the expression of genes
They play a vital role in research, diagnostics, and therapeutics to study expression of genes
and to control diseases by gene silencing.
The study shows that even small, tissue-specific changes in the expression of genes
can have noticeable morphological effects.
FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes
involved in cell growth, proliferation, differentiation, and metabolism.
Michael Holick, concluded that, "Our data suggest that any improvement in vitamin D status will significantly affect expression of genes
that have a wide variety of biologic functions of more than 160 pathways linked to cancer, autoimmune disorders, and cardiovascular disease, which have been associated with vitamin D deficiency.
A study carried out by researchers at the National Institutes of Health and colleagues found that, unlike many other cell growth regulators, MYC does not turn genes on or off, but instead boosts the expression of genes
that are already turned on.
The study results showed that feeding krill powder in addition to a high fat diet to mice with persistent inflammation increased degradation of fatty acids, reduced the generation of fat, and lowered the expression of genes
involved in cholesterol and glucose metabolism that resulted in improved blood and liver lipid levels.
Neonatal genistein treatment (50 pg/kg body weight/day) resulted in substantial changes in the expression of genes
that modulate neonatal oviduct morphogenesis, including Hoxa, Wnt, and hedgehog signaling genes.
A molecular analysis showed that apoptosis was triggered by decreasing the expression of genes
that cancer cells use to maintain their survival, and increasing the expression of genes
that promote apoptosis.
The new study, however, suggests that in the pathogenic stomach bacterium Clostridium difficile, this RNA structure acts as a sort of sensor to help regulate the expression of genes
, probably to help the bacterium manipulate human cells.
In order to analyze the potential adaptation to acidic conditions, RNA from unadapted and acid-adapted cells in hummus at both temperatures was extracted and analyzed for expression of genes
involved in log and stationary phase acid tolerance responses: ompR, cadC and fur.
Analysis of the data showed that the test moisturisers induced different effects on mRNA expression of genes
involved in lipid synthesis.