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Related to Fas ligand: Fas protein, CD95, Fas receptor, Granzyme B


 (lī′gənd, lĭg′ənd)
An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex.

[From Latin ligandus, gerundive of ligāre, to bind; see ligate.]


(ˈlɪɡənd; ˈlaɪ-)
(Chemistry) chem an atom, molecule, radical, or ion forming a complex with a central atom
[C20: from Latin ligandum, gerund of ligāre to bind]


(ˈlaɪ gənd, ˈlɪg ənd)

1. a molecule, as an antibody, hormone, or drug, that binds to a receptor.
2. a molecule, ion, or atom that is bonded to the central metal atom of a coordination compound.
[1945–50; < Latin ligandus, ger. of ligāre to bind, tie]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ligand - a substance (an atom or molecule or radical or ion) that forms a complex around a central atom
substance - a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
References in periodicals archive ?
Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma.
7) from Santa Cruz Biotechnologies (Dallas, TX, USA); HLA-DR/DP/DQ (HB145) from Loke Diagnostics (Aarhus, Denmark); Fas Ligand (10F2) from Serotec (Oxford, UK); and PD-L1 from Sino Biological (Beijing, China).
NF-[kappa]B activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability," Stroke, vol.
FAS and FAS ligand expression on lymphocytes directly correlate with mortality (61).
Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.
1c] as the most informative markers for glucose tolerance; fasting glucose, insulin, Fas ligand, complement C3, and PAI-1 as most informative for insulin sensitivity; and fasting glucose, insulin, PAI-1, ACE, and IL-2Ra as most informative for insulin secretion.
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis.
Expression of Fas ligand and sFas ligandin human gastric adenocarcinomas.
There was an increase in plasma levels of sFas antigen and Fas ligand over time in asymptomatics.
The aim of this study was to determine the changes in complete blood count (CBC), NK cell count and activity, perforin expression, and Fas and soluble Fas ligand (sFas-L) levels in immunocompetent children with VZV infection and define any possible relations between the levels and development of varicella complications.
The extrinsic pathway, by contrast, is triggered by extracellular events through the binding to cell surface receptors of tumor necrosis factor (TNF) superfamily death ligands, including TNF-[alpha] and Fas ligand.
Key words: apoptosis, caspases, complement C5, complement complex C5b-9, experimental allergic encephalomyelitis, Fas ligand, oligodendrocyte, multiple sclerosis, phosphatidylinositol-3 kinase, T lymphocyte.