ceruloplasmin

(redirected from Ferroxidase)
Also found in: Medical, Encyclopedia.

ce·ru·lo·plas·min

 (sə-ro͞o′lō-plăz′mĭn)
n.
A blood glycoprotein to which copper is bound during transport and storage.

ceruloplasmin

(sɪˌruːləʊˈplæzmɪn)
n
a protein responsible for copper detoxification, found in the blood
References in periodicals archive ?
ceruloplasmin) CP Copper-binding (6-7 atoms per molecule) glycoprotein with ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species.
Among the minerals required for skeletal formation, colloidal system maintenance, acid--base balance, and enzyme activities, Cu has been considered increasingly important in crustacean nutrition because of its functions in hematopoiesis and in numerous Cu-dependent enzymes including lysyl oxidase, cytochrome c oxidase, ferroxidase, tyrosinase, and superoxide dismutase (SOD) (Lall 2002).
We previously developed an immunoassay for CP, a ferroxidase that plays a role in copper and iron metabolism, and characterized the antibody pair for this blood protein (15).
More than 90% of copper is bound to ceruloplasmin, an [alpha]2-globulin with ferroxidase activity.
Ceruloplasmin is an [alpha]2-glycoprotein synthesized in hepatocytes that binds plasma copper and has ferroxidase activity.
It is remarkably similar to 1-I-ferritin that assembles into typical ferritin shells within mitochondria and has ferroxidase activity (41).
CP also has an important role as a ferroxidase and superoxide scavenger.
An important feature of H subunit is its ferroxidase activity that facilitates the oxidation of Fe2+ (predominant form in the cytosol) to Fe3+ to be bound to ferritin.
Ceruloplasmin is a copper-dependent ferroxidase that likely cooperates with ferroportin to export iron from macrophages, hepatocytes, and intestinal mucosal cells (Fig.
Ceruloplasmin has ferroxidase activity as well as ferritin H subunits, and patients with a congenital absence of ceruloplasmin develop severe iron overload (17,18).
2+] among other substrates (1), and the catalytic oxidation of ferrous ions or ferrous complexes to the ferric state by ceruloplasmin is termed as ferroxidase I activity.