Experimental treatments for refractory pruritus include phototherapy, plasmapheresis, albumin dialysis, ileal bile acid transporter-inhibitors, methotrexate, and fibrates
Six studies accepted the stable use of hypolipemiants for a minimum period (prior to the beginning of the study) of 8 weeks (18); 3 months (15,29); 6 months (25); one of them accepted the use of statin, but excluded who were on fibrates
for 6 weeks before the beginning of the study (28); and on another, the use of fibrate
or niacin was allowed, but the use of niacin for less or equal to 3 months prior to the beginning of the study was exclusion criteria (26).
Where do niacin, fibrates
, ezetimibe, and fish oils fit in?
Jawed Akhtar from USA spoke about Lipid Lowering beyond Statins and Fibrates
Niacin, fish oil and fibrates
lower TGs, but whether adding these medications to statins prevents additional heart attack or stroke remains unclear.
You're also more likely to have myalgia if you take other cholesterol-lowering medications called fibrates
, calcium channel blockers such as verapamil (Calan, Isoptin), the blood thinner warfarin, cimetidine (Tagamet), which is used to treat reflux disease, and some drugs used to treat heart arrhythmias.
In addition, it is known that fibrates
may attenuate platelet activation by inhibiting ADP-induced platelet aggregation (8).
Therefore, other triglyceride-lowering agents may be needed to treat very high triglycerides; these agents include omega-3 fatty acids, niacins, and fibrates
A total of 27% reported using lipid-lowering medications at baseline; roughly half used statins and half used fibrates
, and cholesteryl ester transfer protein (CETP) inhibitors were all found to raise HDL cholesterol levels, but none of these was able to lower all-cause mortality rates, coronary heart disease-related mortality rates, or the risk of stroke compared with placebo.
Nearly all current cholesterol medicines -- fibrates
, niacin and top-selling statins -- are decades old.
decrease the amountof fats (lipids) in the blood.