filaggrin


Also found in: Thesaurus, Medical, Wikipedia.

filaggrin

(ˈfɪləˌɡrɪn)
n
a protein found in skin cells
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.filaggrin - the main protein of the keratohyalin granules; "the specific target of the immune response in rheumatoid arthritis is filaggrin"
protein - any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
Mentioned in ?
References in periodicals archive ?
Severe skin inflammation and filaggrin mutation similarly alter the skin barrier in patients with atopic dermatitis.
Filaggrin skin barrier gene mutation status was determined in all infants.
In addition to the classic predictors of AD development such as family history and urban environment, elevated transepidermal water loss in newborns has been found to be a strong predictor of AD, regardless of filaggrin (FLG) gene status.
It is now recognized that intrinsic, genetically mediated skin barrier dysfunction, as elucidated with filaggrin gene mutations, explains tendencies to xerotic skin in early life, manifested by increased transepidermal water loss, lower hydration levels, and a "leakier" epidermis that may increase cutaneous sensitization.
To maintain skin hydration, abundant intracellular filaggrin proteins are hydrolyzed into amino acids and their deiminated products, collectively referred to as the "natural moisturizing factors" (Gruber et al.
Filaggrin repeat number polymorphism is associated with a dry skin phenotype.
Citrullinated synthetic peptides included those derived from the filaggrin, EBV nuclear antigen, or IgG sequences; CPs included recombinant rat filaggrin or mutated human vimentin.
Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood Barker JNWN, Palmer CAN, Zhao Y, Liao H, Hull PR, Lee SP, Allen MH, Meggitt SJ, Reynolds NJ, Trembath RC, Irwin Mclean WH J Invest Dermatol, 2007, 127, 564-567
Some studies suggest that patients with atopic dermatitis may have increased rates of allergic sensitization, and filaggrin mutations have been found in patients with atopic dermatitis and in patients with ACD to nickel.
Mutations in FLG gene encoding filaggrin are a highly significant risk factor for atopic dermatitis.
Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment.