Aduro engineered these platforms to express Francisella
tularensis antigens, and both vaccine platforms demonstrated significant protection in tularemia challenge models in rats.
tularensis, and Borrelia burgorferi sensu lato, were negative.
Trius will then apply its structure-based drug design and development capabilities in an effort to optimize promising antibacterial compounds for activity against gram-negative biodefense pathogens such as Yersinia pestis, Francisella
tularensis and Burkholderia pseudomallei.
The contract covers development, manufacturing, and regulatory activities that would position Achaogen's lead antibiotic candidate ACHN-490 for the treatment of certain biothreat agents, including Yersinia pestis, which causes bubonic plague, and Francisella
tularensis, which causes tularemia.
Serologic results for Borrelia bergdorferi, Rickettsia rickettsii, Anaplasma phagocytophilum, and Francisella
tularensis were negative.
Tularemia is a bacterial disease commonly transmitted to humans through contact with infected rodents or rabbits or through insects that carry Francisella
tularensis, the causative agent of tularemia, which is classified by the Centers for Disease Control as a Category A Bioterrorism Agent and is prioritized by the Department of Defense and Department of Health and Human Services as one of the most serious biological weapons, along with anthrax and plague.
bioterrorism agents, such as Brucella and Francisella
tularensis) may cause lab infections.
diphtheriae infection and Bacillus anthracis, Yersinia pestis, and Francisella
The poster, entitled "Efficacy of Cethromycin in A Murine-Aerosol Model of Francisella
tularensis (ShuS4)," summarizes efficacy data demonstrating the potency of cethromycin against tularemia from a mouse study conducted by the U.
Procedures are available for those agents thought to be those most likely to be involved in an event, such as the smallpox and other viruses, Bacillus anthracis, Francisella
tularensis and Yersinia pestis.
This award will fund the discovery and development of proprietary Achaogen compounds to combat biothreat strains of Gram-negative bacteria such as Yersinia pestis, the causative agent of bubonic plague, and Francisella
tularensis, the causative agent of tularemia.
Tularemia is a bacterial zoonotic disease caused by a gram-negative coccobacillus, Francisella
tularensis; the most virulent subspecies, tularensis (type A), is found in North America, but subspecies holarctica (type B) occurs throughout the Northern Hemisphere (1-4).