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Freund's adjuvant |
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| We have found in preliminary studies that the same pattern of TLR expression is induced by CB3 and the Mycobacterium in complete Freund's adjuvant, which suggests a common mechanism of activation (16). The Company postulates that an immune-based therapy containing TCR peptides with Incomplete Freund's Adjuvant (IFA) stimulates regulatory T-cells capable of suppressing these autoreactive pathogenic T-cells. Rabbits were immunized subcutaneously with 10 [micro]g of protein with complete Freund's adjuvant, followed by a second 10-[micro]g injection 1 month later with incomplete Freund's adjuvant and a final 10-[micro]g booster after another month. |
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