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Related to G-protein: Adenylyl cyclase


(jē′prō′tēn′, -tē-ĭn)
Any of a class of cell membrane proteins that transmit signals from certain receptors to effector enzymes, enabling the cell to regulate its metabolism in response to hormones and other extracellular stimuli.

[From GTP-binding regulatory protein.]
References in periodicals archive ?
These unusual antibodies may have the potential to hit targets that have not been amenable to human antibodies, including g-protein coupled receptors (GPCRs) and ion channels, both therapeutically important classes of proteins.
Among their topics are the role of mass transport limitation and surface heterogeneity in the biophysical characterization of macromolecular binding processes, a capture coupling method for the covalent immobilization of hexahistidine-tagged proteins for SPR, a high-throughput kinase assay based on SPR, interactions between carbohydrates and lectins, the membrane binding of antimicrobial peptides, incorporating a transmembrane protein into a supported three-dimensional matrix of liposomes for SPR studies, and applying SPR spectroscopy to study G-protein coupled receptor signaling.
The pathogenetic relevance of the C825T polymorphism relies on the fact that the 825T allele of GNB3 is related to enhanced stimulated G-protein activation in cell lines from hypertensive patients (16, 17).
Their results suggest that neuropeptide hormones use a novel binding mechanism to activate a class of receptors called G-protein coupled receptors (GPCRs).
Takeda, Heptares start joint studies on G-protein coupled reactor
The applicant hypothesises that reproductive hormones and their metabolites play an integral role in beta-cell adaptation in pregnancy through altered nuclear farnesoid-X-receptor (FXR) and G-protein coupled receptor TGR5 activity in the enteroendocrine L-cells and pancreatic islets.
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in US$ Billion.
We are currently investigating the functional link of G-protein activation to regulation of ecdysteroidogenesis.
Transfluor technology comprises cell-based fluorescent assays for imaging and G-protein coupled receptor (GPCR) studies that are used with imaging platforms, such as Molecular Devices' Discovery-1 and ImageXpress systems.
Many forms of cellular communication rely on G-protein linked signaling pathways to amplify the intracellular effects of certain molecules.
Under the terms of the agreement, DanioLabs will use their proprietary IBD model to screen compounds from Oxagen's G-protein coupled receptor (GPCR) program.
Rockville, MD) has patented human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques.