G-protein


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Related to G-protein: Adenylyl cyclase

G-pro·tein

(jē′prō′tēn′, -tē-ĭn)
n.
Any of a class of cell membrane proteins that transmit signals from certain receptors to effector enzymes, enabling the cell to regulate its metabolism in response to hormones and other extracellular stimuli.

[From GTP-binding regulatory protein.]
References in periodicals archive ?
Drug discovery company Confo Therapeutics stated on Monday that it plans to discover, develop and commercialise novel, small molecule agonists of an undisclosed G-protein coupled receptor (GPCR) for the treatment of neurological and developmental disorders under a research collaboration and license agreement with Roche.
Ogeda is a clinical-stage firm that discovers and develops small molecule drugs targeting G-protein coupled receptors.
q] class is one subfamily of the G protein alpha subunit family and is comprised of four genes: G-protein subunit Galphaq (GNAQ), GNA11, GNA14, and GNA15 (Davignon et al.
Global Markets Direct's, 'Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) - Pipeline Review, H1 2016', provides in depth analysis on Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) targeted pipeline therapeutics.
Our Main Focus Would Be Looking At G-Protein Coupled Receptor And Ion Channel Receptor Activation Or Inhibition.
Background: G-protein [sz]-polypeptide 3 (GNB3) is a [sz] subunit isoform of G-protein that plays important role in signal transduction of membrane G-protein coupled receptors (GPCRs).
Their results suggest that neuropeptide hormones use a novel binding mechanism to activate a class of receptors called G-protein coupled receptors (GPCRs).
Takeda, Heptares start joint studies on G-protein coupled reactor
The molecule, CXCR4, is part of a large family of proteins called G-protein coupled receptors (GPCRs).
Among their topics are the role of mass transport limitation and surface heterogeneity in the biophysical characterization of macromolecular binding processes, a capture coupling method for the covalent immobilization of hexahistidine-tagged proteins for SPR, a high-throughput kinase assay based on SPR, interactions between carbohydrates and lectins, the membrane binding of antimicrobial peptides, incorporating a transmembrane protein into a supported three-dimensional matrix of liposomes for SPR studies, and applying SPR spectroscopy to study G-protein coupled receptor signaling.
Two biochemical pathways stem from a cell surface receptor called G-protein coupled receptor (GPCR).
The pathogenetic relevance of the C825T polymorphism relies on the fact that the 825T allele of GNB3 is related to enhanced stimulated G-protein activation in cell lines from hypertensive patients (16, 17).