Embelin also exhibited significant and dose dependant delayed onset of clonic-tonic actions and protection from PTZ induced mortality and may be interfering with GABAergic
mechanism to exert its anticonvulsant effect (Gale 1992).
We expect this to be the first of many discoveries by Neuralstem of key fate-determining factors that will enable controlled differentiation of neural stem cells into specific types of neurons, such as dopamine-producing neurons, acetylcholine-producing neurons, and GABAergic
neurons," said Richard Garr, President and CEO of Neuralstem.
Neurophysiology of Substantia Nigra Dopaminergic Neurons: Modulation by GABAergic
On the other hand, GABAergic
stimulation of TSH release in both males and ovariectomized female rats has also been reported (58).
Evidence for testrogen-receptive GABAergic
neurons in the preoptic/anterior hypothalamic area of the rat brain.
Furthermore, several neuroimaging studies of alcoholics have shown deficits in the GABA receptors for the chemical benzodiazepine, which facilitates inhibitory GABAergic
transmission (Abi-Dargham et al.
In the study, human CNTF was found to preserve several populations of striatal cells, including GABAergic
, cholinergic and diaphorase-positive neurons, in addition to critical non-striatal regions associated with cognitive capabilities.
Dissociation of [35S]t-butylbicyclophosphorothionate binding differentiates convulsant and depressant drugs that modulate GABAergic
system represents a promising future target of new pharmacological strategies that treat anxiety (Domschke and Zwanzger, 2008).
Rats trained to self-administer alcohol during withdrawal show neurochemical and neuropharmacologic changes indicative of alterations in GABAergic
, dopaminergic, and serotonergic function in specific components of the extended amygdala.
a7nAChR stimulation enhances inhibitory GABAergic
Neuroadaptive processes in GABAergic
and glutamatergic systems in benzodiazepine dependence.