knock-down

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Related to Gene knockdown: Gene knockout
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.knock-down - strong enough to knock down or overwhelm; "a knock-down blow"
strong - having strength or power greater than average or expected; "a strong radio signal"; "strong medicine"; "a strong man"
References in periodicals archive ?
The kit has multiple advantages for RNAi applications and compatible with siRNA complexing and administration to achieve sustained gene knockdown (gene silencing via in vivo mRNA knockdown) after a single injection.
Diamond commented, "The purpose of this study is to utilize TNBC cell line gene knockdown models to investigate further the role of p53 and p73 in mediating sensitivity to ENMD-2076.
The company has previously reported target gene knockdown of 99% in monkeys after a single subcutaneous injection of 1 mg/kg, with >80% knockdown for 3 months.
The authors used the luciferase reporter assay and Western blot analysis to determine COX-2 induction by Cr(VI); dominant negative mutant, genetic knockout, gene knockdown, and chromatin immunoprecipitation approaches were used to elucidate the signaling pathway leading to COX-2 induction.
They found that they could achieve the same level of gene knockdown as conventional nanoparticle delivery, but with about one-thousandth as many particles.
Bar graph depict that about 50 percent gene knockdown was achieved following transfection with 100 nM siRNA concentration (Figure 3B).
The Ad vector has high infection efficiency with a remarkable gene knockdown effect in the JEG-3 cells cultured in vitro.
The resulting target gene knockdown reduces gene expression in a way that is highly selective and specific.