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Related to Gene knockdown: Gene knockout
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.knock-down - strong enough to knock down or overwhelm; "a knock-down blow"
strong - having strength or power greater than average or expected; "a strong radio signal"; "strong medicine"; "a strong man"
References in periodicals archive ?
AUMsilence self-delivering oligos achieve highly efficient and potent antisense-based gene knockdown.
Among the topics are nanoparticulate systems for dental drug delivery, lipid nanoplatforms for pulmonary drug delivery, potential nanocarriers for brain drug delivery, nanomaterials and cancer therapy, nanomedicines against chronic inflammatory diseases, and nanotechnology in gene knockdown and miRNA replacement in vivo.
The Increased Expressions of FOXOs Protect Hearts against H/R-Induced Oxidative Stress in CD38 Gene Knockdown H9c2 Cells.
The company has previously reported target gene knockdown of 99% in monkeys after a single subcutaneous injection of 1 mg/kg, with >80% knockdown for 3 months.
The authors used the luciferase reporter assay and Western blot analysis to determine COX-2 induction by Cr(VI); dominant negative mutant, genetic knockout, gene knockdown, and chromatin immunoprecipitation approaches were used to elucidate the signaling pathway leading to COX-2 induction.
They found that they could achieve the same level of gene knockdown as conventional nanoparticle delivery, but with about one-thousandth as many particles.