epistasis

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e·pis·ta·sis

 (ĭ-pĭs′tə-sĭs)
n. pl. e·pis·ta·ses (-sēz′)
1. An interaction between nonallelic genes in which the genotype at one locus affects the expression of alleles at another locus.
2. A film that forms over the surface of a urine specimen.
3. The suppression of a bodily discharge or secretion.

[Greek, stoppage, from epistanai, to stop, check : ep-, epi-, epi- + histanai, to place; see stā- in Indo-European roots.]

ep′i·stat′ic (ĕp′ĭ-stăt′ĭk) adj.

epistasis

(ɪˈpɪstəsɪs)
n
1. (Medicine) obsolete scum on the surface of a liquid, esp on an old specimen of urine
2. (Medicine) med the arrest or checking of a bodily discharge, esp bleeding
3. (Genetics) genetics Also called: hypostasis the suppression by a gene of the effect of another gene that is not its allele
[C19: from Greek: a stopping, from ephistanai to stop, from epi- + histanai to put]
epistatic adj

e•pis•ta•sis

(ɪˈpɪs tə sɪs)

n., pl. -ses (-ˌsiz)
a form of interaction between nonallelic genes in which one combination of such genes has a dominant effect over other combinations.
[1915–20; probably after epistatic (1907) (probably epi- + static, taken as meaning “standing above”)]
ep•i•stat•ic (ˌɛp əˈstæt ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epistasis - the suppression of a gene by the effect of an unrelated gene
biological process, organic process - a process occurring in living organisms
References in periodicals archive ?
SCIENTISTS IN the US have uncovered a key genetic interaction underpinning glaucoma which could lead to the development of new drugs.
They consider such topics as reducing dimensionality in the search for gene-gene interactions, high-throughput genetic interaction studies, gene-gene and gene-environment interaction in rheumatoid arthritis, functional studies of gene-gene interaction of autoimmune disease, and network biology empowering the detection and understanding of interactions between genetic factors in the development of complex phenotypes.
The classical epistatic model included all the possible genetic interaction effects among multiple loci.
Using behavioral genetic interaction models, the investigators found significant relationships between habitual sleep duration, and genetic and shared environmental influences on BMI.
Association of schizophrenia with DTNBP1 but not with DAO, DADA, NRG 1 and RGS4 nor their genetic interaction.
To our knowledge, this is the first study to show behavioral and genetic interaction in functioning and aging, and shows people are already pre-selected, that there are genes that interact with behavior to affect mobility," he said.
BIND's data model was the first of its kind to be peer-reviewed prior to database development, and is now a mature standard data format spanning molecular interactions, small molecule chemical reactions, interfaces from three-dimensional structures and genetic interaction networks.
Kaplan M, Renbaum P, Levy-Lahad E, et al: Gilbert's syndrome and G6PD deficiency: a dose dependent genetic interaction crucial to neonatal hyperbilirubinemia.
So far, identification of presumptive genetic interaction using the multiple regression models has been demonstrated only with inter-crossed populations.
Similarly, genes that have similar genetic interaction profiles are likely to influence each other's effects, and Huber, Boutros and colleagues can now suggest such 'friends'-i.
The potential interaction effects have not been analyzed in many genetic studies of complex traits because of the increasing number of genetic interaction parameters (Frankel and Schork, 1996).
MetaDrug(TM) is also complimentary with MetaCore(TM) enabling researchers to build and analyze protein-protein, protein-ligand and genetic interaction networks using GeneGo's comprehensive databases of human biology and active chemistry.