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Related to Genetic interaction: epistasis


n. pl. e·pis·ta·ses (-sēz′)
1. An interaction between nonallelic genes in which the genotype at one locus affects the expression of alleles at another locus.
2. A film that forms over the surface of a urine specimen.
3. The suppression of a bodily discharge or secretion.

[Greek, stoppage, from epistanai, to stop, check : ep-, epi-, epi- + histanai, to place; see stā- in Indo-European roots.]

ep′i·stat′ic (ĕp′ĭ-stăt′ĭk) adj.


1. (Medicine) obsolete scum on the surface of a liquid, esp on an old specimen of urine
2. (Medicine) med the arrest or checking of a bodily discharge, esp bleeding
3. (Genetics) genetics Also called: hypostasis the suppression by a gene of the effect of another gene that is not its allele
[C19: from Greek: a stopping, from ephistanai to stop, from epi- + histanai to put]
epistatic adj


(ɪˈpɪs tə sɪs)

n., pl. -ses (-ˌsiz)
a form of interaction between nonallelic genes in which one combination of such genes has a dominant effect over other combinations.
[1915–20; probably after epistatic (1907) (probably epi- + static, taken as meaning “standing above”)]
ep•i•stat•ic (ˌɛp əˈstæt ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epistasis - the suppression of a gene by the effect of an unrelated gene
biological process, organic process - a process occurring in living organisms
References in periodicals archive ?
SCIENTISTS IN the US have uncovered a key genetic interaction underpinning glaucoma which could lead to the development of new drugs.
Such applications could be employed to cure genetic disease in humans or to limit the fitness of disease-carrying organisms--but the intricacies of genetic interaction mean those uses could also have unintended consequences, perhaps triggering other diseases.
They consider such topics as reducing dimensionality in the search for gene-gene interactions, high-throughput genetic interaction studies, gene-gene and gene-environment interaction in rheumatoid arthritis, functional studies of gene-gene interaction of autoimmune disease, and network biology empowering the detection and understanding of interactions between genetic factors in the development of complex phenotypes.
Via a large-scale genetic interaction map, Rfa1 has negative genetic interactions with Csm3, Mrc1, and Tof1 (2).
The classical epistatic model included all the possible genetic interaction effects among multiple loci.
Using behavioral genetic interaction models, the investigators found significant relationships between habitual sleep duration, and genetic and shared environmental influences on BMI.
Due to complexity of ethnic and genetic processes in the age of broad migration and genetic interaction of Asian tribes with Slavic, Finno-Ugric and Turkic ethnic groups in Central Asia, it is impossible to establish authentically the basic components that formed the basis for the formation of the gene pool of indigenous population - Kazakhs by using traditional historical methods.
Association of schizophrenia with DTNBP1 but not with DAO, DADA, NRG 1 and RGS4 nor their genetic interaction.
To our knowledge, this is the first study to show behavioral and genetic interaction in functioning and aging, and shows people are already pre-selected, that there are genes that interact with behavior to affect mobility," he said.
BIND's data model was the first of its kind to be peer-reviewed prior to database development, and is now a mature standard data format spanning molecular interactions, small molecule chemical reactions, interfaces from three-dimensional structures and genetic interaction networks.
Kaplan M, Renbaum P, Levy-Lahad E, et al: Gilbert's syndrome and G6PD deficiency: a dose dependent genetic interaction crucial to neonatal hyperbilirubinemia.
Given enough time, all isolated populations will eventually evolve into new species, assuming of course that the population does not first become extinct or reestablish genetic interaction with other populations of the same species.