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n. pl. e·pis·ta·ses (-sēz′)
1. An interaction between nonallelic genes in which the genotype at one locus affects the expression of alleles at another locus.
2. A film that forms over the surface of a urine specimen.
3. The suppression of a bodily discharge or secretion.

[Greek, stoppage, from epistanai, to stop, check : ep-, epi-, epi- + histanai, to place; see stā- in Indo-European roots.]

ep′i·stat′ic (ĕp′ĭ-stăt′ĭk) adj.


1. (Medicine) obsolete scum on the surface of a liquid, esp on an old specimen of urine
2. (Medicine) med the arrest or checking of a bodily discharge, esp bleeding
3. (Genetics) genetics Also called: hypostasis the suppression by a gene of the effect of another gene that is not its allele
[C19: from Greek: a stopping, from ephistanai to stop, from epi- + histanai to put]
epistatic adj


(ɪˈpɪs tə sɪs)

n., pl. -ses (-ˌsiz)
a form of interaction between nonallelic genes in which one combination of such genes has a dominant effect over other combinations.
[1915–20; probably after epistatic (1907) (probably epi- + static, taken as meaning “standing above”)]
ep•i•stat•ic (ˌɛp əˈstæt ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epistasis - the suppression of a gene by the effect of an unrelated gene
biological process, organic process - a process occurring in living organisms
References in periodicals archive ?
The company's patented technology simulates the complex genetic interactions that occur naturally in human reproduction and the inheritance of disease risk.
Now, I will pioneer the concept of genetic interactions between coding (chromatin-factors) and non-coding RNAs (miRNAs) using primary human epidermal stem cells as a well-characterised and clinically relevant model system.
One possible explanation for these peculiar genetic interactions for this trait can be the contribution of unique combinations of genes in inheritance of this trait in specific crosses (Azizi et al.
This is the case when pathogens interfere with our biochemical machinery but if the right combination of chemicals could be mustered to target these genetic interactions in the pathogens themselves, we could turn the tables on them.
In recent years, public outcry has included concerns over potential genetic interactions between wild and cultured animals in cases where natural beds of shellfish lie in close proximity to intensively cultured locations.
The researchers generated their interactome -- the whole set of interactions within a cell -- using the BioGrid database of protein and genetic interactions.
Between the lines of the genetic code; genetic interactions in understanding disease and complex phenotypes.
Via a large-scale genetic interaction map, Rfa1 has negative genetic interactions with Csm3, Mrc1, and Tof1 (2).
According to Kapahi, while living for hundreds of years would be difficult, the study has raised the prospect of anti-ageing treatments based on genetic interactions.
To identify significant genetic interactions with the boys' peripubertal TEQs, we fitted separate multivariate Cox models for each SNP, which included an interaction term consisting of the number of minor alleles (0, 1, or 2) multiplied by the boys' peripubertal [log.
Genetic interactions are important factors to complex biological traits, because most biological phenotypes result from the complex interplay of many genes and environmental factors.
2) The majority of studies addressing cardiovascular disease pharmacogenomics examine the potential genetic interactions of these drugs in large segments of the cardiovascular disease pharmaceutical markets, e.