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or germ line  (jûrm′līn′)
1. The gamete-producing cells in a sexually reproducing organism, by means of which genetic material is passed on to subsequent generations.
2. The collection or sequence of such cells in an individual and all its descendants.
References in periodicals archive ?
The new research comes less than six months after the National Academies of Science, Engineering and Medicine recommended that scientists limit their trials of human germ-line editing to diseases that could not be treated with "reasonable alternatives" - at least for now.
Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma.
Efficient genetic modification and germ-line transmission of primordial germ cells using piggyBac and Tol2 transposons.
ERVs are relics of past infections, resulting from viral genomic integrations that occur in host germ-line cells, and are in turn passed down from parents to offspring as part of the host genome," the researchers wrote in the study.
The project exploits a genetic approach to ablate the Socs3 gene from the female germ-line and addresses the role of Socs3 gene during mouse oocyte maturation and fertilisation, e.
In traditional electroporation methods, either levels of transfer have been low with few studies showing germ-line transmission and expression [15] or the device used is no longer commercially available [16].
In 3 percent of the group, healthy-tissue analysis found a potentially detrimental germ-line mutation predisposing patients to cancer.
The British parliament has decided to allow doctors in the United Kingdom to be the first in the world to perform germ-line gene therapy.
Personalis' sequencing depth and coverage uniformity enhances sensitivity for mosaic variants, enabling mosaic detection in probands, as well as germ-line mosaicism detection in the parents for more precise recurrence risk prediction.
The findings also show that mutations in the germ-line are present in all cells of the children, including their own germ cells.