thp

(redirected from Gli2)
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Related to Gli2: Gli3

thp

also t.hp.
abbr.
thrust horsepower
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References in periodicals archive ?
Tras la union al receptor PTCH1 en las celulas intersticiales fetales, DHH induce respuestas intracelulares por medio de factores de transcripcion GLI1 y GLI2 (Szczepny et al.
They validated these results experimentally by assessing the expression of [beta]-catenin, WIF-1, GLI2, androgen receptor, and epithelial-mesenchymal transition-related markers with Western blot and immunohistochemistry.
Other candidate genes are involved in the physiology of growth, such as GLI2 in myogenesis and osteoblast differentiation [31], NYAP2 in brain size, neurite elongation and neuronal morphogenesis [32], and ZFPM2 in adipogenesis [33].
14-3-3[zeta] Turns TGF-[beta]s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2," Cancer Cell, vol.
Specific bone morphogenic proteins have been found to play a role in this process, and one of these is stimulated by Gli2 [14,18-20].
Vanderbilt University researchers found TGF-[beta]1 increases parathyroid hormone-related protein (PTHrP) activity by stimulating the Gli2 signaling molecule, speeding bone loss.
Analysis showed that darinaparsin reduced the levels of the transcription factor Gli2, a downstream effector of the activated Hedgehog pathway which is elevated in certain cancers.
Specifically, the researchers found that arsenic trioxide blocks the ability of a protein called Gli2 to induce gene transcription in the nucleus.
Asimismo, se han encontrado mutaciones en 9 genes como causantes de HPE: SHH, PTCH, GLI2, DHCR7, ZIC2, TDGF1, TGIF, FAST1 y SIX3.
The transcription factor Gli2 plays a key role within this pathway, indeed, Gli2 is responsible for the marked apoptosis resistance of the BCCs.