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Tras la union al receptor PTCH1 en las celulas intersticiales fetales, DHH induce respuestas intracelulares por medio de factores de transcripcion GLI1 y GLI2 (Szczepny et al.
They validated these results experimentally by assessing the expression of [beta]-catenin, WIF-1, GLI2, androgen receptor, and epithelial-mesenchymal transition-related markers with Western blot and immunohistochemistry.
Other candidate genes are involved in the physiology of growth, such as GLI2 in myogenesis and osteoblast differentiation , NYAP2 in brain size, neurite elongation and neuronal morphogenesis , and ZFPM2 in adipogenesis .
Average daily production of biogas for treatments Gli0 (control), Gli2, Gli4 and Gli6%.
14-3-3[zeta] Turns TGF-[beta]s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2," Cancer Cell, vol.
Specific bone morphogenic proteins have been found to play a role in this process, and one of these is stimulated by Gli2 [14,18-20].
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephalylike features.
Vanderbilt University researchers found TGF-[beta]1 increases parathyroid hormone-related protein (PTHrP) activity by stimulating the Gli2 signaling molecule, speeding bone loss.
Analysis showed that darinaparsin reduced the levels of the transcription factor Gli2, a downstream effector of the activated Hedgehog pathway which is elevated in certain cancers.
Specifically, the researchers found that arsenic trioxide blocks the ability of a protein called Gli2 to induce gene transcription in the nucleus.
Asimismo, se han encontrado mutaciones en 9 genes como causantes de HPE: SHH, PTCH, GLI2, DHCR7, ZIC2, TDGF1, TGIF, FAST1 y SIX3.
The transcription factor Gli2 plays a key role within this pathway, indeed, Gli2 is responsible for the marked apoptosis resistance of the BCCs.
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- Glendower Owen
- Glenn Curtiss
- Glenn Hammond Curtiss
- Glenn John Herschel, Jr.
- Glenn Miller
- Glenn T. Seaborg
- Glenn Theodore Seaborg
- glenoid cavity
- glenoid fossa
- glial cell
- glib ice
- glide bomb
- glide by
- glide mode
- glide path
- glide slope
- glide time
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- GLI EA
- GLI family zinc finger 2
- GLI family zinc finger 3
- GLI family zinc finger 4
- GLI-Kruppel family member GLI2
- GLI-Kruppel family member GLI3
- GLI-Kruppel family member GLI4
- Glišic, Milovan
- GLI3 form of 190 kDa
- GLI3 full length protein
- glia cell
- glia cells
- glia cells
- glia cells
- Glia Fiber Acid Protein
- Glia Fibrillary-Associated Protein
- Glia Maturation Factor, Beta
- Glia Maturation Factor-Gamma
- glia-activating factor GAF
- Glia-Derived Neurite Promoting Factor
- glia-derived nexin
- Gliadel Wafer