Merck a leading science and technology company, today announced that the British Medicines and Healthcare products Regulatory Agency (MHRA), has approved on November 2 an updated labeling for Glucophage XR
(extended release metformin) for the treatment of patients with type 2 diabetes.
There were also two unblinded reference arms with Glucophage XR
dosed once-daily at 1000 and 2000 milligrams.
To respond to patients' individual needs, the company went on developing new formulations and presentations of metformin including Glucophage XR
, an extended release formulation, Glucophage Powder Formulation in Sachets, and Glucovance (metformin and glibenclamide), a fixed-dose combination therapy containing two anti-hyperglycemic compounds indicated for the treatment of type 2 diabetes.
Fatima, a diabetic patient, had voiced apprehensions about the tablet, Glucophage XR
(500mg), saying it had shown up virtually unchanged in her stool.
Drugs with significant potential that are having generic equivalents hit the market are: Ortho-Novum 7/7/7 * (birth control) Ortho Tri-Clyclen * (birth control) Accupril (blood pressure) Nolvadex (breast cancer) Topamax (anti-convulsant) Glucophage XR
(diabetes) Monopril (blood pressure) Remeron (antidepressant) Alphagan (glaucoma) Serzone (antidepressant) Glucovance (diabetes) Glucotrol XL (diabetes) Wellbutrin SR (antidepressant) Zyban (smoking cessation) Neurontin (anti-convulsant) Tiazac (blood pressure) Prozac (antidepressant) Prilosec (gastritis)
Depomed will also receive ongoing royalty payments from Teva on sales by IVAX and Teva of generic Glucophage XR
There were also two comparator arms with Glucophage XR
dosed once-daily at 1,000 and 2,000 milligrams.
Metformin Hydrochloride, a generic version of Bristol Myers Squibb's Glucophage XR
brand is mainly used to improve glycemic control in patients suffering from type-2 diabetes.
Fatima, a diabetic patient, said she took the drug Glucophage XR
(500mg) but noticed that the undissolved tablet passed out in her stool.
Accupril - Agrylin - Axid - Biaxin - Celexa - Cipro - Difl ucan - Duragesic - Effexor - Flonase - Floxin/Occufl ox - Glucophage XR
- Glucotrol XL - Glucovance - Lotensin - Metaglip - Mobic - Monopril - Novantrone - Paraplatin - Paxil - Pravachol - Proscar - Retrovir - Rocephin - Romazicon - Tambocor - Ultram - Zaditor - Zestril/Prinivil - Zithromax - Zocor - Zofran - Zoloft
According to the company, Metformin Hydrochloride is a generic version of Bristol Myers Squibb s Glucophage XR
brand, which is used to enhance glycemic control in patients suffering from type-2 diabetes.
(77) is top for NID, with Januvia (73) and Victoza (71) ranking behind.