The ongoing, NIH-funded GAIT (Glucosamine/Chondroitin Arthritis Intervention Trial) study is comparing glucosamine hydrochloride
(Gch), chondroitin sulfate (CS), celecoxib (Celebrex[R]), Gch + CS, and placebo within a starting population of almost 1600 subjects with osteoarthritis.
People that start taking glucosamine, for example, may not receive immediate relief of pain, rather it takes six to eight weeks to see the benefits symptomatically," said Tom Fox, director of marketing, Emerging Products, Cargill Acidulants Division, Naperville, IL, (suppliers glucosamine hydrochloride
under the trade name Regenasure[TM], which does not use shellfish as its source).
The new products include 12-hour Vitamin C; 12-hour Ester-C[R]; 12-hour glucosamine hydrochloride
; 12-hour glucosamine/chondroitin/MSM; 12-hour glucosamine hydrochloride
sulfate complex and 8 hour caffeine.
Navy on 34 males with chronic pain and radiographic degenerative disease of the knee found that patients who took the therapeutic combination of CS (1200mg/day), glucosamine hydrochloride
(1500mg / day) and manganese ascorbate (226mg/day) experienced significant relief of knee pain but no improvement in function (14).
There have been criticisms of the design: glucosamine hydrochloride
was used even though most of the published trials used glucosamine sulfate; there is no plan in the protocol to do subset analysis based on severity of baseline knee osteoarthritis (OA) even though there are indications that more severely progressed OA is less responsive; and studies conducted on knee space narrowing published after GAIT began suggest that narrowing in untreated joints is slower than GAIT assumed, meaning that the trial may not be adequately powered (i.
One: Glucosamine Sulfate and Glucosamine Hydrochloride
Our first take home message from the meeting on which we are all agreed, is that glucosamine hydrochloride
is just a placebo.
PLoS One reported the outcome of a double-blind, crossover study that found supplementation with chondroitin sulfate and glucosamine hydrochloride
, a nutritional combination used to alleviate symptoms of arthritis, was associated with a reduction in C-reactive protein (CRP), a marker of inflammation.
DS (1,500 mg of glucosamine hydrochloride
and 1,200 mg of chondroitin sulfate in capsule form) to a Brazilian prescription brand (1,500 mg of glucosamine sulfate and 1,200 mg of chondroitin sulfate) in either a sachet or a capsule formulation.
Symptomatic treatment for the pain may be preferred and if canidryl is not working there are some veterinary nutritional supplements containing greenlipped muscle, glucosamine hydrochloride
and/or chondroitin sulphate that will do no harm and are worth a try but are unlikely to solve the problem.
Research: This study compared the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride
(CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain.
It also claims that the active ingredients in Elations, glucosamine hydrochloride
and chondroitin sulfate cannot improve joint health or relieve joint pain.