NASDAQ: ALNY) presented initial data at the American Society of Nephrology Kidney Week 2017 annual meeting from Part B of its ongoing Phase 1/2 study of lumasiran, an investigational RNAi therapeutic targeting glycolate
oxidase (GO), in the first two cohorts of patients (6-19 years old) with Primary Hyperoxaluria Type 1 (PH1) dosed with lumasiran or placebo, the company said.
, hippurate, and trigonelline were important to distinguish the patients prone to OA progression from those who were not prone (42).
Gelatin, chitosan, sodium alginate, cyclodextrins, aliphatic polyesters, such as homo and copolymers of lactate and glycolate
(PLA, PGA, and PLGA), poly and caprolactone (PCL) and the polyhydroxyalkanoates, known as PHA, cellulose and cassava starch, can be used as formulation components, among others (Kumari, Yadav, & Yadav, 2010).
In a study aiming to evaluate the oral insulin bioavailability of nanoliposomes containing CH and bile salts (BS), nanoliposomes were formulated with sodium glycolate
(SGC), sodium taurocholate (STC), and sodium deoxycholate (SDC).
At three representative hot-air drying temperatures, the thermo-oxidative stability will be examined using high IV melt resins, which were catalyzed by antimony glycolate
, titanic acid/magnesium hydroxide, or aluminum/potassium glycolate
, in the presence or absence of phosphoric acid.
Urinary levels of glycolate
are abnormal in Type 2 PH; in Type 3 PH, urinary levels of glycerate are abnormal.
Resistance has been related with the presence of ruminal MFA-degrading microorganisms in the rumen, which contain a dehydrogenase enzyme that breaks the carbon-fluorine bond, producing fluorine and glycolate
(FETZNER & LINGENS, 1994).
The vast majority (80% to 90%) of oxalates found within the body are produced endogenously (from within) in the liver as an aspect of glycolate
HAO1 encodes glycolate
oxidase (GO), an enzyme involved in producing oxalate.
and glyoxylate metabolism in HepG2 cells.
metabolism of the three submerged aquatic angiosperm during aging.
Inactive ingredients consist of: dibasic calcium phosphate, sodium starch glycolate
, magnesium stearate, gelatin, titanium dioxide, FD&C Yellow #6, FD&C Red #3, FD&C Red #40, shellac, and black iron oxide.