Both leuprolide and deslorelin acetate are GnRH
superagonists that function to downregulate the hypothalamic-pituitary-gonadal axis by negative feedback, after an initial surge to suppress reproduction and associated hormones, including follicle-stimulating hormone and luteinizing hormone.
The exact impact of these protocols has been controversial following early reports that GnRH
antagonists were associated with lower pregnancy rates.
The current study was conducted to determine and compare the GnRH
antagonist protocol during early and late follicular phase with GnRH
antagonist (flexible) and long GnRH
agonist protocols in patients with PCOS undergoing ICSI.
agonists are used at a high dose to chronically decrease hormonal release.
Orchiectomy induces significant elevation of FSH levels while gonadotropin-releasing hormone (GnRH
) agonists inhibit the serum FSH levels, albeit to a significantly lesser extent than GnRH
Activity was assessed via GnRH
challenges; a classic technique where injections of GnRH
are used to investigate whether individuals are reproductively capable (Wingfield et al.
This improved therapeutic profile will allow GnRH
antagonists to command premium over GnRH
The test of testosterone, LH and GnRH
hormones concentration was performed by ELISA method on serums after separating serum by centrifuging.
The introduction of newer GnRH
analogues, the GnRH
antagonists, created the potential for milder stimulation protocols that are better tolerated and less costly, have a quicker onset of action, result in a lower incidence of luteinising hormone (LH) surge, and are associated with a lower multiple pregnancy rate.
Remarkable progress has been made in understanding the molecular and cellular mechanisms underlying the pubertal activation of the GnRH
generator, which involve the combined effects of intra-hypothalamic actions of inhibitory and stimulatory neuropeptids (Genazzani et al.
Given that patients with hormone receptor--positive disease in the current study who had evidence of ovarian recovery were immediately suppressed without data on long-term recovery and that breast cancer outcome data are not available, and given as well the potential adverse effects on disease outcome, the use of GnRH
agonists concomitant with chemotherapy cannot be recommended as a standard treatment and should be approached with caution in women with hormone-sensitive disease," they said.
Saglikli olan cocuklarda pubertenin neden geciktigi sorusunun yaniti tam olarak alinmis olmamakla birlikte GnRH
reseptor mutasyonlari, LH reseptor gen polimorfizmi, leptin ve reseptorlerinin mutasyonlari, FGFR1 mutasyonu ile ilgili calismalar devam etmektedir (4).